代谢综合征患者血单核细胞Toll样受体4表达变化

发布时间：2018-01-03 04:08

本文关键词：代谢综合征患者血单核细胞Toll样受体4表达变化　出处：《中国动脉硬化杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的比较代谢综合征(MS)患者及单纯高血压(EH)患者血单核细胞Toll样受体4(TLR4)及血浆高敏C反应蛋白(hs-CRP)的表达。方法采用流式细胞仪检测62例EH患者及45例MS患者血单核细胞TLR4的阳性率,同时检测血浆hs-CRP浓度。并将TLR4及hs-CRP分别与年龄、性别、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、TLR4、hs-CRP行单因素相关分析,然后进行多元逐步回归分析。结果 MS组TLR4(5.7%±1.2%)、hs-CRP(5.6±0.9 mg/L)与单纯EH组(分别为5.3%±0.9%、5.0±0.8 mg/L)患者差异均有统计学意义(t值分别为-3.274、-2.225,P值分别为0.028、0.01);单因素相关分析显示,TLR4和hs-CRP均与TC、LDL、Hb A1c、FBG、餐后2 h血糖(2h PBG)呈正相关(P0.05),TLR4与hs-CRP也呈正相关(P0.05);多元逐步回归分析显示,影响TLR4最显著因素为hs-CRP、Hb A1c(β值分别为0.745、0.244,P值分别为0.000、0.004),影响hs-CRP最显著因素为TLR4(β=0.943,P=0.000)。结论MS患者单核细胞TLR4阳性率、血浆hs-CRP均较单纯EH患者高,MS患者单核细胞TLR4阳性率与血浆hsCRP水平呈正相关,TLR4可能参与了MS发生和发展。
[Abstract]:Objective to compare the monocyte Toll receptor 4 (TLR4) and plasma Gao Min C-reactive protein hs-CRP (hs-CRP) in patients with metabolic syndrome (MS) and hypertension (EH) patients. Methods the positive rate of monocyte TLR4 in 62 patients with EH and 45 patients with MS was detected by flow cytometry. At the same time, the plasma hs-CRP concentration was determined. TLR4 and hs-CRP were compared with age, sex, total cholesterol, triglyceride, high density lipoprotein (HDL). Low density lipoprotein (LDL), fasting blood glucose (FBGN), HbA1C (HbA1C) and TLR4hs-CRP were analyzed by univariate correlation analysis. Then multivariate stepwise regression analysis was performed. Results in MS group, TLR4 was 5.7% 卤1.2%). Hs-CRP(5.6 卤0. 9 mg / L) and EH group (5.3% 卤0.9%, respectively). The difference of 5.0 卤0.8 mg / L was statistically significant (P = -3.274) -2.225 (P = 0.028). Univariate correlation analysis showed that both TLR4 and hs-CRP were positively correlated with TCLDLL HbA1cFBGand 2 h postprandial blood glucose (P0.05). There was also a positive correlation between TLR4 and hs-CRP. Multivariate stepwise regression analysis showed that the most significant factor affecting TLR4 was hs-CRP HbA1c (尾 = 0.745U 0.244p, P = 0.000, respectively). The most significant factor affecting hs-CRP was TLR4 (尾 -0.943). Conclusion the positive rate of monocyte TLR4 in MS patients is significant. The positive rate of monocyte TLR4 in patients with MS was higher than that in patients with simple EH. There was a positive correlation between the positive rate of monocyte TLR4 and the level of plasma hsCRP. TLR4 might be involved in the pathogenesis and development of MS.
【作者单位】：徐州医学院第二附属医院检验科;徐州医学院;徐州医学院第二附属医院心内科;
【分类号】：R589;R446.11
【正文快照】： 代谢综合征(metabolic syndrome,MS)已成为现代社会危害人类健康的主要疾病之一[1]。有研究显示,MS患者发生心脑血管事件的危险性显著大于单纯性高血压病(essential hypertension,EH)和糖尿病患者,其危害巨大,控制也相当困难[2]。其发病机制复杂,目前尚不完全明确。Toll样受体

【共引文献】