不同糖尿病风险评估量表筛查效果比较及中国量表的修订

发布时间：2018-01-03 10:45

本文关键词：不同糖尿病风险评估量表筛查效果比较及中国量表的修订　出处：《北京体育大学》2016年硕士论文　论文类型：学位论文

【摘要】：研究目的：选择芬兰Lindstrom版糖尿病评估量表、德国Matthias版糖尿病评估量表、中国董氏版糖尿病评估量表、日本Yoriko版糖尿病评估量表和泰国Aeklakorn版糖尿病评估量表,对同一批研究对象进行筛查,以评价5个量表在中国人群糖尿病风险筛查中的应用效果,并且对董建军等人编制的中国版量表进行适当调整、修订。研究方法：选取北京某医院参与日常体检者,对其进行问卷调查；由经过培训的调查人员对其进行测量,并记录其年龄、性别、身高、体重、腰围、臀围等形态指标以及空腹血浆葡萄糖和餐后2小时血浆葡萄糖指标。用受试者工作特征曲线(ROC曲线)的曲线下面积(AUC)反应筛查方法的准确度；用约登指数计算量表风险得分的最佳切点。研究结果：(1)年龄、超重与肥胖(BMI或腰围)和糖尿病家族史3个因素权重之和在芬兰Lindstrom版、德国Matthias版、中国董氏版、日本Yoriko版、泰国Aeklakorn版量表中分别是61.5%、66.6%、50.0%、68.8%、64.7%,均超过50%。(2)芬兰Lindstrom版、德国Matthias版、中国董氏版、日本Yoriko版、泰国Aeklakorn版量表曲线下面积(AUC)分别为0.770(959%CI:0.707-0.826, p0.0001).0.658(95%CI:0.589-0.722,p=0.0001).0.819(95%CI:0.760-0.869, p0.0001).0.654(95%CI:0.585-0.718,p=0.0001)和0.645(95%CI：0.576-0.710,p=0.0004)。(3)中国改编版量表曲线下面积(AUC)为0.814(95%CI：0.755-0.865,p0.0001)。研究结论：(1)年龄、超重与肥胖、遗传因素(糖尿病家族史)是糖尿病评估筛查中不可缺少的内容。(2)通过对5种量表糖尿病“诊断”的真实性、可靠性和收益价值比较后发现,芬兰Lindstrom版、中国董氏版量表的筛查效果优于德国Matthias版、日本Yoriko版、泰国Aeklakorn版量表,较适用于中国人群的糖尿病筛查；(3)用于中国人群的研究中,中国董氏版(或芬兰Lindstrom版)糖尿病评估量表的最优切点是63分(或12分),其筛查具有较高的灵敏度和特异度。(4)改编版量表包括年龄、BMI、腰围、收缩压、舒张压、体力活动、DM家族史和高血糖史共8个条目(评分范围为0～124分),它具有较好的筛查效果(最优切点是63分),适用于中国人群的糖尿病筛查。
[Abstract]:The purpose of the study is to choose Finland Lindstrom version of the diabetes assessment scale, the German Matthias version of the diabetes assessment scale, China's version of the diabetes assessment scale, Yoriko Japanese version of the diabetes assessment scale and Thailand Aeklakorn version of the diabetes assessment scale, screening for the same object of study, to evaluate the 5 scale effect in diabetes risk Chinese screening in the crowd, and the Chinese edition was compiled by Dong Jianjun, the table of the appropriate adjustments revised. Methods: select a hospital in Beijing to participate in the daily check-up on the questionnaire survey; carry on the measurement by the investigation personnel through training, and record the age, gender, height, weight, waist circumference hip circumference, morphological index, fasting plasma glucose and postprandial 2 hour plasma glucose index. Then the receiver operating characteristic curve (ROC curve) area under the curve (AUC) was screened The accuracy of the calculation method; optimal cut point scale risk score with Youden index. Results: (1) age, overweight and obesity (BMI or waist) and family history of diabetes and the weights of 3 factors in Finland Lindstrom version, Matthias version of Germany, Japan China Dong's version, Yoriko version, Aeklakorn version of Thailand the table is respectively 61.5%, 66.6%, 50%, 68.8%, 64.7%, more than 50%. (2) Lindstrom Finland version, the German version of Matthias, China Dong's version, Japanese version Yoriko, Aeklakorn version of the Thailand scale area under the curve (AUC) were 0.770 (959%CI: 0.707-0.826, P0.0001.0.658 (95%CI:0.589-0.722), p=0.0001 (.0.819) 95%CI:0.760-0.869, P0.0001).0.654 (95%CI:0.585-0.718, p=0.0001) and 0.645 (95%CI:0.576-0.710, p=0.0004). (3) China adaptation scale area under the curve (AUC) was 0.814 (95% CI:0.755-0.865, P0.0001). Conclusions: (1) age, overweight and obesity. Transfer factor (family history of diabetes) is an indispensable content of diabetes screening assessment. (2) of the 5 kinds of real scale diabetes "diagnosis", comparing the reliability and yield value after the discovery, Finland is better than the Lindstrom version, China Dong version screening scale effect of the German Matthias version, the Japanese version of Yoriko, Thailand Aeklakorn version scale is suitable for screening for diabetes China population; (3) to study Chinese population, China Dong's Version (or Finland Lindstrom) diabetes assessment scale optimal point is 63 (or 12), the screening has high sensitivity and specificity. (4) revised version the scale included age, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, physical activity, family history of DM and hyperglycemia in history of a total of 8 items (scores ranged from 0 to 124 points), it has better screening effect (the optimal cut-off point of 63 points), suitable for Chinese diabetes screening population.

【学位授予单位】：北京体育大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R587.1

【相似文献】