原发性高血压患者血压变异性与糖尿病的相关性

发布时间：2018-01-08 17:27

本文关键词：原发性高血压患者血压变异性与糖尿病的相关性　出处：《中国老年学杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的探讨合并2型糖尿病(T2DM)的高血压患者与单纯原发性高血压患者动态血压水平及血压变异性的相关性。方法以800例合并T2DM的原发性高血压患者及800例单纯原发性高血压患者为研究对象,监测研究对象日间、夜间及24 h收缩压及舒张压变异性,并进行对比分析,研究原发性高血压患者血压变异性与糖尿病的相关性。结果高血压合并T2DM组24 h平均收缩压、夜间平均收缩压均明显高于高血压组(均P0.05),高血压合并T2DM组收缩压昼夜差值、舒张压昼夜差值均明显低于高血压组(均P0.05);高血压合并T2DM组24 h收缩压标准差、日间收缩压标准差、日间收缩压变异系数、夜间收缩压标准差、夜间收缩压变异系数、夜间舒张标准差、血压晨峰均明显高于高血压组(均P0.05);经相关分析发现,患者血糖水平与24 h收缩压标准差、24 h收缩压变异系数、日间收缩压标准差、日间收缩压变异系数、日间舒张标准差、日间舒张压变异系数、夜间舒张标准差、血压晨峰呈正相关(均P0.05)。结论原发性高血压合并T2DM患者血压变异性较单纯原发性高血压患者增大,提示糖尿病合并原发性高血压时对患者昼夜血压调节损害较大并可能与血糖水平有关。
[Abstract]:Objective to study the patients with type 2 diabetes mellitus (T2DM) patients with hypertension and simple correlation in patients with essential hypertension ambulatory blood pressure levels and blood pressure variability. Methods 800 patients with T2DM in patients with essential hypertension and 800 cases of primary hypertension patients as the research object, the monitoring object of study during the day, night and 24 h systolic blood pressure and diastolic blood pressure variability, and the analysis of correlation between patients with essential hypertension blood pressure variability and diabetes. Results of hypertension combined with T2DM group 24 h mean systolic blood pressure, nighttime average systolic blood pressure was significantly higher than that of the high blood pressure group (P0.05), hypertension group T2DM systolic blood pressure, diastolic blood pressure difference between day and night. The difference between day and night were significantly lower than those in hypertension group (P0.05); hypertension group T2DM 24 h systolic blood pressure standard deviation, daytime systolic blood pressure standard deviation, coefficient of variation of daytime systolic blood pressure, nighttime systolic blood pressure standard deviation, night charge Systolic pressure variation coefficient, night diastolic standard deviation, morning blood pressure peak were significantly higher in hypertension group (P0.05); the correlation analysis showed that blood glucose levels and systolic blood pressure 24 h 24 h standard deviation, coefficient of variation of systolic blood pressure, daytime systolic blood pressure standard deviation, coefficient of variation of daytime systolic blood pressure, diastolic daytime daytime standard deviation. The coefficient of variation of diastolic blood pressure, nighttime diastolic standard deviation, correlation of morning blood pressure peak positive (P0.05). Conclusion hypertension blood pressure variability in patients with T2DM compared with patients with hypertension increased, suggesting that diabetic patients with primary high blood pressure in patients with circadian blood pressure regulation and greater damage may be related to blood glucose levels.

【作者单位】：昆明市第一人民医院老年病科;
【分类号】：R544.1;R587.1
【正文快照】： 原发性高血压的靶器官损害累及心、脑、肾和血管等重要脏器,与脑卒中、缺血性心脏病的非预期死亡明显相关〔1,2〕。高血压的危害除与血压水平有关外,还取决于同时存在的其他心血管危险因素,如糖尿病、血脂异常、吸烟、肥胖等。文献报道高血压的导致的靶器官受损不仅与24 h血压

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