生脉注射液联合格列美脲治疗气阴两虚型2型糖尿病的临床疗效及对患者血清炎性因子的影响

发布时间：2018-01-08 19:03

  本文关键词：生脉注射液联合格列美脲治疗气阴两虚型2型糖尿病的临床疗效及对患者血清炎性因子的影响　出处：《中国实验方剂学杂志》2016年04期 　论文类型：期刊论文

  更多相关文章： 生脉注射液 格列美脲 型糖尿病 糖化血红蛋白 白细胞介素-β

【摘要】：目的:探讨生脉注射液联合格列美脲治疗气阴两虚型2型糖尿病的临床效果及对血清炎性因子的影响。方法:选取2013年2月—2015年2月来滨州市中医医院就诊的2型糖尿病患者152例,采用随机数字法分为观察组77例和对照组75例。对照组给予格列美脲进行治疗,观察组在对照组治疗的基础上联合生脉注射液治疗。观察比较两组患者的临床有效率,空腹血糖(FBG),餐后2 h血糖(2 h PBG),糖化血红蛋白(Hb A1c)的改变及血清高敏C反应蛋白(hs-CRP),肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL~(-1)β)水平变化及不良反应情况。结果:观察组总有效率92.21%,明显高于对照组的78.67%(P0.05)。两组FBG[(5.87±0.32)VS(10.63±0.53)mmol·L~(-1)],2 h PBG[(6.52±1.22)VS(11.24±2.72)mmol·L~(-1)],Hb A1c[(4.42±0.37)%VS(6.21±0.52)%]比较,观察组明显低于对照组(P0.05)。治疗后,两组患者的hs-CRP,TNF-α,IL~(-1)β水平显著降低(P0.05),且两组hs-CRP[(2.25±0.73)VS(3.37±1.01)g·L~(-1)],TNF-α[(1.56±0.47)VS(2.23±0.44)ng·L~(-1)],IL~(-1)β[(15.36±3.70)VS(22.94±3.81)ng·L~(-1)]比较,观察组水平明显低于对照组(P0.05)。两组患者治疗期间不良反应主要为呕吐、腹泻和低血糖,经对症治疗后均痊愈,不良反应发生率比较差异无统计学意义。结论:生脉注射液联合格列美脲治疗气阴两虚型2型糖尿病的疗效明显,同时可降低患者体内炎性因子的水平,从而可能延缓气阴两虚型2型糖尿病并发症的发生,值得临床推广使用。
[Abstract]:Objective: To investigate the clinical effect of Shengmai injection combined with glimepiride in the treatment of type 2 diabetes of Qi Yin deficiency and effect on serum inflammatory factors. Methods: 152 patients with type 2 diabetes from February 2013 to February 2015 to visit Binzhou City Chinese medicine hospital were divided into observation group 77 cases and control group 75 cases randomly. The control group given glimepiride treatment, the observation group of Shenmai injection combined with students on the basis of the control group. The clinical treatment of the two groups were observed and compared with the efficiency of fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PBG), glycosylated hemoglobin (Hb A1c) and changes of serum high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF- alpha), interleukin -1 (IL~ (-1) 3) level changes and adverse reactions. Results: the total efficiency of the observation group was 92.21%, significantly higher than the control group 78.67% (P0.05). Two groups of FBG[(5.87 + 0.32) VS (10.63. 0.53)mmol路L~(-1)],2 h PBG[(6.52卤1.22)VS(11.24卤2.72)mmol路L~(-1)],Hb A1c[(4.42卤0.37)%VS(6.21卤0.52)%]姣旇緝,瑙傚療缁勬槑鏄句綆浜庡�圭収缁�(P0.05).娌荤枟鍚，

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