非编码RNA与肝脏糖脂代谢调控

发布时间：2018-01-10 13:11

本文关键词：非编码RNA与肝脏糖脂代谢调控　出处：《生理科学进展》2016年03期 　论文类型：期刊论文

【摘要】：随着经济的迅速发展、人们饮食习惯的改变和身体活动的减少,糖尿病成为了现代社会的非传染性的流行病,给家庭和社会造成了极大的危害和经济负担。其中以全身性胰岛素抵抗及胰岛功能衰竭为主要发病特征的2型糖尿病(type 2 diabetes,T2D)已在世界范围引起广泛关注。T2D的发生发展涉及许多组织及糖代谢的各个环节,遗传因素和环境因素共同引起的糖脂代谢通路任一环节的失调均可导致T2D的发生。近年来,包括microRNA(miRNA)及长非编码RNA(LncRNA)在内的非编码RNA(ncRNA)的发现及其在人体生理和病理生理过程中的重要调控作用不断被揭示,为进一步了解T2D的发病机制注入了新理念和信息。miRNAs及LncRNAs的表达具有组织特异性,其表达水平的异常通常与疾病相关。本文主要对miRNAs和LncRNAs在肝脏糖脂代谢调控及T2D的发生发展中的作用及机制的最新研究进展作简要综述。
[Abstract]:With the rapid development of economy, the change of people's eating habits and the decrease of body activity, diabetes has become a non-infectious epidemic in modern society. It has caused great harm and economic burden to the family and society. Type 2 diabetes mellitus type 2 diabetes is characterized by systemic insulin resistance and islet failure. T2D) has attracted worldwide attention. The occurrence and development of T2D involves many tissues and various aspects of glucose metabolism. Genetic factors and environmental factors caused by any link of glycolipid metabolic pathway disorder can lead to the occurrence of T2D in recent years. Noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (LncRNAs). The discovery and important regulatory role in human physiological and pathophysiological processes have been revealed. In order to further understand the pathogenesis of T2D, new ideas and information. MiRNAs and the expression of LncRNAs have tissue specificity. The abnormality of its expression level is usually associated with disease. This article mainly reviews the role and mechanism of miRNAs and LncRNAs in the regulation of hepatic glycolipid metabolism and the development of T2D. Summary
【作者单位】：北京大学医学部基础医学院生理与病理生理系北京大学医学部非编码RNA医学研究中心;
【基金】：国家自然科学基金(81471035;81322011)资助课题
【分类号】：R587.1
【正文快照】： 糖尿病是一组以慢性血葡萄糖水平增高为主要特征的代谢性疾病,是一种严重危害人类健康的慢性非传染性疾病。随着经济的发展和人们生活方式的改变,糖尿病的患病率呈上升趋势,并成为了全球性的健康挑战。2010年,在全球范围内3.9%的死亡(三百四十万人)和3.8%的伤残调整生命年(dis

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