糖代谢异常患者血清脂肪细胞脂肪酸结合蛋白的变化及其临床意义

发布时间：2018-01-11 14:37

本文关键词：糖代谢异常患者血清脂肪细胞脂肪酸结合蛋白的变化及其临床意义　出处：《中国糖尿病杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的观察不同血糖水平血清脂肪细胞脂肪酸结合蛋白(A-FABP)水平,探讨其与IR的相关性。方法选取NGT组55名、IGT组53例及T2DM组56例,测定各组血清A-FABP、FPG、2 hPG、TC、TG、FIns等指标,计算BMI,WHR及胰岛素抵抗指数(HOMA-IR),分析A-FABP与IR的相关性。结果 T2DM组血清A-FABP水平高于IGT组和NGT组[(71.14±10.03)vs(36.69±8.01)vs(19.49±2.98)mg/L,P0.05]。相关分析显示,血清A-FABP水平与BMI、WHR、TC、TG、HDL-C、LDL-C、HbA_1c、2 hPG、高敏C反应蛋白(hsC-RP)、HOMA-IR相关(r=0.739、0.320、0.202、0.213、0.695、0.248、0.842、0.441、0.354、0.695,P0.05或P0.01)。多元回归逐步分析显示,BMI、WHR、HbA_1c、HOMA-IR是影响血清A-FABP的独立危险因素(t=2.621、4.461、7.362、3.875,P0.05)。结论 A-FABP与IR关系密切,随着IR程度的加重,A-FABP水平逐渐升高。
[Abstract]:Objective to observe the level of serum fatty acid binding protein A-FABPin in adipocytes at different blood glucose levels and to explore its correlation with IR. Methods 55 patients in NGT group were selected. 53 cases in IGT group and 56 cases in T2DM group were tested for serum A-FABPFPGN 2 h PGN TGV TGG FIns and BMI were calculated. The correlation between A-FABP and IR was analyzed. Results the serum A-FABP level in T2DM group was higher than that in IGT group and NGT group. [71.14 卤10.03g / L, 36.69 卤8.01g / L, 19.49 卤2.98mg / L, respectively. The correlation analysis showed that there was no significant difference between the two groups (P < 0.05). Serum A-FABP level and HsC-RPP-HsC-RP1hPGand HbA1hPGand HbA1hPGand HbA1hPGand HsC-RP1hPG1hPGand HbA1hPGand HsC-RP1hPG1hPGand HsC-RP1hPG1hPG@@. The HOMA-IR correlation was 0.739n0.320g / 0.202n 0.2130.695U 0.248t0. 442 / 0.441/ 0.354. Multivariate regression analysis showed that BMIA WHRX HbA1c. HOMA-IR is an independent risk factor affecting serum A-FABP. Conclusion A-FABP is closely related to IR, and the level of A-FABP increases with the severity of IR.
【作者单位】：三峡大学仁和医院检验科;三峡大学仁和医院内分泌科;
【分类号】：R587.1
【正文快照】： 脂肪细胞脂肪酸结合蛋白(A-FABP)又称为Ap2或P15蛋白,属于脂质结合蛋白超家族成员,相对分子质量为14?15 kDa,主要表达于脂肪细胞和巨噬细胞,具有促进c~Jun氨基端激酶(JNK)的磷酸化和使致炎细胞因子生成[1]。A-FABP基因位于8号染色体q21区域,该区域与糖代谢平衡关系密切,因此,A

【相似文献】