2型糖尿病所致缺血性脑血管病斑块形成过程中血脂组分变化的意义

发布时间：2018-01-13 21:25

本文关键词：2型糖尿病所致缺血性脑血管病斑块形成过程中血脂组分变化的意义　出处：《中国老年学杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的探讨2型糖尿病(T2DM)所致缺血性脑血管病板块形成过程中血脂组分的变化及意义。方法选取2012年3月至2015年3月在该院住院并接受治疗的300例T2DM患者,分为两组各150例。比较两组患者血糖和血脂等实验指标的差异;采用回归分析法分析缺血性脑血管病斑块的形成是否与血糖和血脂组分的变化有关。结果两组患者总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)以及甘油三酯(TG)相比差异显著(P0.05);患者的年龄、病程、空腹血糖(FPG)、体质量指数(BMI)、收缩压(SBP)以及血脂成分中的TC、FPG、餐后2 h血糖(2 h PG)、HDL-C、LDL-C和TG均明显相关;Logistic回归分析结果显示血脂成分中仅有HDL-C是缺血性脑血管病斑块形成的危险因素;观察组发生脑梗死的概率明显高于对照组。结论患者的血脂成分在T2DM所致缺血性脑血管病斑块形成过程中有重要作用,其中血脂成分中的TC、FPG、2 h PG、HDL-C、LDL-C和TG均与斑块形成有关,且HDL-C过低是其斑块形成的高危因素;此外,缺血性脑血管斑块的形成会使脑梗死的发生率提高,提示应调节患者的血脂以避免不良并发症的发生。
[Abstract]:Objective to investigate T2DM in type 2 diabetes mellitus. Methods 300 patients with T2DM who were hospitalized in our hospital from March 2012 to March 2015 were selected and treated. The patients were divided into two groups (150 cases each). The differences of blood glucose and blood lipids between the two groups were compared. Regression analysis was used to analyze whether the formation of ischemic cerebrovascular plaque was related to the changes of blood glucose and blood lipids. Low density lipoprotein cholesterol (LDLC) and triglyceride triglyceride (TG) showed significant difference (P 0.05). Age, course of disease, fasting blood glucose (FBG), body mass index (BMI), systolic blood pressure (SBP) and TCfG (2 h postprandial blood glucose). HDL-Con LDL-C and TG were significantly correlated. Logistic regression analysis showed that only HDL-C was the risk factor of plaque formation in ischemic cerebrovascular disease. The probability of cerebral infarction in the observation group was significantly higher than that in the control group. Conclusion the lipid composition of the patients plays an important role in the formation of ischemic cerebrovascular plaques induced by T2DM, among which the TCU FPG is one of the lipid components. LDL-C and TG were related to plaque formation, and low HDL-C was the high risk factor of plaque formation. In addition, the formation of ischemic cerebrovascular plaque will increase the incidence of cerebral infarction, suggesting that the blood lipid should be adjusted to avoid adverse complications.
【作者单位】：郑州大学西亚斯国际学院;
【分类号】：R587.2;R743
【正文快照】： 2型糖尿病(T2DM)患者易发生多种慢性心脑血管并发症,其产生机制复杂〔1〕。而动脉粥样硬化(AS)则起着关键的作用,其产生及发展和血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及甘油三酯(TG)等血脂成分因子具有密切相关性〔2〕,但具体关系尚未清

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