糖尿病患者创面难愈机制及治疗研究进展

发布时间：2018-01-13 23:19

本文关键词：糖尿病患者创面难愈机制及治疗研究进展　出处：《中国糖尿病杂志》2016年12期 　论文类型：期刊论文

更多相关文章： 糖尿病 糖尿病足 伤口愈合 干细胞

【摘要】：糖尿病患者创面难愈是由体内高糖环境和多种生物学因素共同作用导致的疾病。患者皮肤因局部微环境改变及免疫趋化应答功能障碍,容易受损,且创面反复溃烂,难以愈合,最终形成顽固性难愈创面,临床尚缺乏切实有效的治疗方法。对于严重下肢溃疡如糖尿病足的患者,临床多行截肢术阻止创面蔓延,降低患者生活质量,危害患者的生命安全。近年来,随干细胞技术、分子生物学技术、基因技术的不断发展,一些新的治疗方法如利用羊膜搭载表皮干细胞构建组织工程皮肤等被相继应用于治疗创面难愈的实验室和早期临床研究,取得较为满意的疗效。本文从糖尿病患者创面难愈机制,最新临床治疗方法及临床应用探索等方面进行综述。
[Abstract]:The difficult wound healing of diabetic patients is caused by high glucose environment and many biological factors. The skin of diabetic patients is easily damaged because of the changes of local microenvironment and the dysfunction of immune chemotactic response. And the wound repeatedly ulcerated, difficult to heal, finally formed intractable refractory wound, clinical lack of effective treatment. For patients with severe lower extremity ulcers such as diabetic foot. In recent years, with the development of stem cell technology, molecular biology technology and gene technology, clinical amputation has been used to prevent the spread of wound, reduce the quality of life of patients and endanger the life safety of patients. Some new treatment methods, such as the use of amniotic membrane carrying epidermal stem cells to construct tissue engineered skin and so on, have been used in the laboratory and early clinical research for the treatment of difficult wound healing. In this paper, the mechanism of refractory wound healing in diabetic patients, the latest clinical treatment methods and the exploration of clinical application were reviewed.
【作者单位】：安徽医科大学第二临床医学院;
【分类号】：R587.2
【正文快照】： 、糖尿病创面难愈机制糖尿病患者难愈创面是指皮肤在创伤后较长一段时间内难以愈合甚至修复的开放性创面,常因伴随细菌感染或其他并发症而导致创面溃败,使患者面临截肢的危险。糖尿病创面难愈的具体机制尚不清楚,近年来研究发现,其可能与糖尿病患者皮肤的特殊微环境、体内

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