高原肺水肿发病机制及防治研究进展

发布时间：2018-01-15 10:35

本文关键词：高原肺水肿发病机制及防治研究进展　出处：《国际药学研究杂志》2016年01期 　论文类型：期刊论文

【摘要】：高原肺水肿是由于快速进入高原(一般海拔≥2500 m)因缺氧而引起的非心源性肺水肿,为高原地区特发病及常见病,严重威胁人类的健康。其发病机制复杂,可能是由于通气/血流比例失调、化学感受器异常变化、水通道蛋白减少、肺微血管变化以及基因等多种因素共同作用导致的,至今仍不完全清楚。治疗高原肺水肿主要应尽快脱离低压缺氧环境,并配合吸氧或服用利尿剂、激素等能降低肺动脉压的药物,严重时要联合用药。本文介绍了高原肺水肿的流行病学特征、各种发病机制的研究以及防治高原肺水肿的手段、方法和药物,以期能对相关医务人员和从事高原活动的人群提供参考。
[Abstract]:High altitude pulmonary edema is due to rapidly entering high altitude (general altitude of more than 2500 m) caused by hypoxia and non cardiogenic pulmonary edema, as plateau idiopathic disease and common disease, a serious threat to human health. The pathogenesis is complex, may be due to the ventilation / perfusion ratio, chemoreceptor abnormal changes of water channel protein reduce induced pulmonary microvascular changes and genetic factors, is still unclear. The treatment of high altitude pulmonary edema should be mainly from the hypoxia environment as soon as possible, and with oxygen or diuretics, hormones and other drugs can reduce pulmonary artery pressure, severe combination. This paper introduces the epidemiological features of high altitude pulmonary the pathogenesis of edema, a variety of research and prevention of high altitude pulmonary edema by means of methods and drugs, in order to provide reference for relevant medical personnel and engaged in activities of the plateau population.

【作者单位】：第四军医大学药学院药物研究所;
【基金】：国家“重大新药创制”科技重大专项资助项目(2012ZX09J12109-04C)
【分类号】：R594.3
【正文快照】： 高原肺水肿(high altitude pulmonary edema,HAPE)是人们快速进入高原地区由于机体对高原低压缺氧环境的不适应导致代偿失调所引起的特发性疾病,是高原病中常见的急、重症,大多病情危重,进展及变化迅速,若不及时诊治,可很快危及生命,对进入高原地区的人群危害性较大[1]。随着

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