系统性红斑狼疮与TNIP1基因相关性的meta分析

发布时间：2018-01-15 13:14

本文关键词：系统性红斑狼疮与TNIP1基因相关性的meta分析　出处：《扬州大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：采用meta分析的方法,探讨TNIP1基因多态性与系统性红斑狼疮易感性的关系。方法：通过计算机检索全面检索PuMed、Web of Science和EMbase、万方等数据库,查找关于TNIP1基因rs7708392或rs10036748位点多态性与SLE相关性的文献,检索时间至2015年2月5日。采用主题词和关键词进行检索,英文检索词包括“TNIP1"、"TNFAIP3 interacting protein 1"、"systemic lupus erythematosus"、"SLE","polymorphism"。以PubMed为例,其检索内容为：(fNFAIP3 interacting protein 1 OR TNIP1) AND (systemic lupus erythematosus OR SLE) OR (polymorphism)。按照质量评价标准由两名评价员分别对检索的文献采用Newcastle-Ottawa Scale量表进行质量评价,根据纳入和排除标准独立提取资料,意见不一致时协商解决。用Cochrane协作网提供的RevMan5.2统计软件进行meta分析。结果：最终纳入研究的有12篇文献。其中关于TNIP1基因rs7708392位点多态性与SLE的病例对照研究有10个,关于TNIP1基因rs10036748位点多态性与SLE的病例对照研究有6个。提取数据后,进行meta分析,结果显示：1.从整体上,关于TNIP1基因rs7708392位点,我们纳入10个研究,病例组等位基因C频率明显高于对照组[OR=1.23,95%CI(1.12,1.34),P0.001]。而关于TNIP1基因rs10036748位点,我们纳入6个研究。病例组等位基因T频率明显高于对照组[OR=1.29,95%CI(1.24,1.34),P0.001]。TNIP1基因rs10036748位点分层分析。2.在亚群研究中,TNIP1基因rs7708392位点上,欧洲人群共涉及4个研究,病例组等位基因C频率明显高于对照组,C：T的OR=1.29(95%CL:1.23-1.35);亚洲人群共纳入6项研究,病例组等位基因C频率较对照组高,但没有统计学意义,C：T的OR=1.14(95%CL：0.92-1.42)。而关于TNIP1基因rs10036748位点,欧洲人群涉及2项研究,合并分析显示T：C的OR=1.31(95%CL：1.25-1.38),病例组等位基因T频率明显高于对照组；亚洲人群涉及4项研究,结果显示T：C的OR为1.25(95%CL:1.18-1.33),病例组等位基因T频率明显高于对照组。结论：整体上,TNIP1基因rs7708392位点上C等位基因和rs10036748位点上T等位基因的基因频率与系统性红斑的易感性有关。在不同种族中,欧洲人群rs7708392位点上C等位基因和rs10036748位点上T等位基因的基因频率与系统性红斑狼疮易感性有关；亚洲人群中rs10036748位点上T等位基因的基因频率与系统性红斑狼疮易感性有关,而rs7708392位点上C等位基因的基因频率与系统性红斑狼疮易感性尚无明显联系。
[Abstract]:Objective: to investigate the relationship between TNIP1 gene polymorphism and susceptibility to systemic lupus erythematosus by meta analysis. Web of Science and EMbase, Wanfang and other databases. To find out the correlation between rs7708392 or rs10036748 polymorphism of TNIP1 gene and SLE. The retrieval time is up to February 5th 2015. Subject words and keywords are used to search. The English key words include "TNIP1". "TNFAIP3 interacting protein 1", "systemic lupus erythematosus", "SLE". "polymorphism". Take PubMed as an example. The contents of the search are:: FNFAIP3 interacting protein 1 OR TNIP1) AND (. Systemic lupus erythematosus OR polymorphism. According to the quality evaluation criteria, two evaluators used Newcastle-Ottawa Scale scale to evaluate the quality of the literature. Independent extraction of information based on inclusion and exclusion criteria. The meta analysis is carried out with the RevMan5.2 statistical software provided by the Cochrane Cooperative Network. The results are as follows:. There were 12 articles included in the study, of which there were 10 case-control studies on rs7708392 locus polymorphism of TNIP1 gene and SLE. There were 6 case-control studies on the polymorphism of rs10036748 locus of TNIP1 gene and SLE. After extracting the data, the results of meta analysis showed that: 1. Regarding the rs7708392 locus of TNIP1 gene, we included 10 studies. The allele C frequency in the case group was significantly higher than that in the control group. [The rs10036748 locus of the TNIP1 gene was 1.12 ~ 1.34 (P0.001). The allele T frequency in the case group was significantly higher than that in the control group. [The rs10036748 locus of the TNIP1 gene was stratified. 2. In the subpopulation study. The allele C frequency in the TNIP1 gene rs7708392 locus was significantly higher in the European population than that in the control group. The order of C: t is 1.299.95 / C: 1.23-1.35; The allele C frequency in the case group was higher than that in the control group, but there was no statistical significance. The OR1.1495 of C: t involves two studies on the rs10036748 locus of the TNIP1 gene. The combined analysis showed that the allele T frequency in the case group was significantly higher than that in the control group. Four studies were conducted in Asian population. The results showed that the OR of T: C was 1.255.95%, and the allele T frequency of the case group was significantly higher than that of the control group. Conclusion: on the whole, the allele T frequency of the case group is higher than that of the control group. The frequency of C allele in rs7708392 locus of TNIP1 gene and T allele in rs10036748 locus were related to susceptibility to systemic erythema. The frequencies of C allele at rs7708392 locus and T allele at rs10036748 locus in European population were related to susceptibility to systemic lupus erythematosus. The frequency of T allele at rs10036748 locus in Asian population is related to susceptibility to systemic lupus erythematosus. However, there was no significant correlation between C allele frequency and systemic lupus erythematosus susceptibility at rs7708392 locus.
【学位授予单位】：扬州大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R593.241

【相似文献】