强直性脊柱炎患者检测骨代谢指标潜在的临床价值

发布时间：2018-01-27 14:39

本文关键词： 强直性脊柱炎(AS) 骨代谢指标 C反应蛋白(CRP) 人类白细胞抗原B(HLA-B)　出处：《中国免疫学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的:探讨骨代谢指标和人类白细胞抗原B27(HLA-B27)在检测强直性脊柱炎(AS)患者的临床意义,并分析其诊断价值。方法:研究对象为94例AS患者、239例其他病种对照和80例健康对照组,并对其结果进行回顾性分析。结果:AS组β-胶原特殊序列(β-CTX)高于对照组,而骨钙素(OC)、25羟基维生素D[25-(OH)D]和甲状旁腺素(PTH)低于对照组(P0.05);AS组C反应蛋白(CRP)和β-CTX呈明显的正相关(P0.01),25-(OH)D呈负相关(P0.05),其他骨代谢指标和CRP无相关性;AS组HLA-B27阳性率明显高于其他组(P0.05),且HLA-B27在诊断AS时具有很高的敏感性和特异性;AS组25-(OH)D检测的敏感性高于β-CTX,但特异性低于β-CTX。结论:骨代谢指标对AS早期筛查,临床诊断有着重要价值,尤其是β-CTX和25-(OH)D的诊断价值更为明显。
[Abstract]:Objective: to investigate the clinical significance of bone metabolism and human leukocyte antigen B27 HLA-B27 in the detection of ankylosing spondylitis (ASA). Methods: 94 patients with as and 239 patients with other diseases and 80 healthy controls were studied. The results were analyzed retrospectively. Results 尾 -CTXs in as group were higher than those in control group, while OCCON 25 hydroxyvitamin D was higher in as group than that in control group. [The levels of PTH and PTH were lower than those of the control group (P 0.05). In as group, there was a negative correlation between C-reactive protein (CRP) and 尾 -CTX (P 0.01) and OHH D (P 0.05), but there was no correlation between other bone metabolism indexes and CRP. The positive rate of HLA-B27 in as group was significantly higher than that in other groups (P 0.05), and HLA-B27 had high sensitivity and specificity in the diagnosis of as. In as group, the sensitivity of 25-OHX was higher than that of 尾 -CTX, but the specificity was lower than that of 尾 -CTX.Conclusion: bone metabolism index has important value in early screening and clinical diagnosis of as. The diagnostic value of 尾-CTX and 25-OHH D was more obvious.
【作者单位】：南昌大学第二附属医院检验科;南昌大学公共卫生学院;
【基金】：江西省科技厅重点科技成果转移转化计划(No.20151BBI90047)和江西省科技厅社发项目(No.2015BBG70154)
【分类号】：R593.23
【正文快照】： (1)本文为江西省科技厅重点科技成果转移转化计划(No.20151BBI90047)和江西省科技厅社发项目(No.2015BBG70154)。(2)南昌大学公共卫生学院,南昌330031。强直性脊柱炎(Ankylosing spondylitis,AS)是一种主要累及中轴关节、肌腱和韧带骨附着点的慢性进行性疾病[1,2],发病机制十

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