蛋白激酶Cβ基因rs16972959多态性与类风湿关节炎的相关性研究

发布时间：2018-01-28 05:19

本文关键词： 多态性单核苷酸关节炎类风湿类风湿因子　出处：《中华疾病控制杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的类风湿关节炎(rheumatoid arthritis,RA)是一种受环境和遗传因素共同影响其易感性的自身免疫性疾病。研究显示蛋白激酶Cβ(protein kinase Cβ,PKCβ)基因与若干自身免疫病相关。本文分析在汉族人群中PKCβ的rs16972959是否与类风湿性关节炎具有相关性。方法本研究采用病例对照研究并收集508例RA患者和503例健康对照。采用TaqMan探针基因分型技术检测病例组和对照组PKCβ基因位点rs16972959的基因型。应用SPSS 16.0进行统计分析。结果 RA病例组和对照组PKCβ基因(rs16972959)等位基因频率分布差异无统计学意义(OR=0.928,95%CI:0.761~1.131,P=0.460),基因型分布差异无统计学意义(GG vs AA:OR=1.054,95%CI:0.632~1.759,P=0.839;GA vs AA:OR=0.963,95%CI:0.570~1.627,P=0.888)。研究发现rs16972959等位基因频率与抗环瓜氨酸肽抗体(anti-cyclic citrullinated peptide,ACCP)有关(P=0.041)。此外,rs16972959基因型与类风湿因子(rheumatoid factor,RF)有关(P=0.042)。但是,本研究没有发现rs16972959与抗角蛋白抗体有关。结论以上研究表明PKCβ基因位点rs16972959与汉族人群RA遗传易感性无关。Rs16972959与部分实验室指标存在关联。
[Abstract]:Objective to study the rheumatoid arthritis of rheumatoid arthritis. RAA is an autoimmune disease affected by both environmental and genetic factors. Studies have shown that protein kinase C 尾 protein kinase C 尾. PKC 尾). The relationship between PKC 尾 rs16972959 and rheumatoid arthritis in Han population was analyzed. Methods A case-control study was conducted and collected in this study. The genotypes of PKC 尾 locus rs16972959 were detected by TaqMan probe genotyping technique in 508 RA patients and 503 healthy controls. SS. Results the PKC 尾 gene of RA patients and controls were analyzed. Rs16972959) there was no significant difference in allele frequency distribution between OR0.928 and Rs16972959. There was no significant difference in genotype distribution between GG and AA:OR=1.054. 95 CI: 0.632U 1.759m Pu 0.839; Ga vs AAORO 0.96395 CI: 0.570 / 1.627. The allele frequency of rs16972959 and anti-cyclic citrullin-peptide antibody were found. Anti-cyclic citrullinated peptide. In addition, rs16972959 genotype was associated with rheumatoid factor. RF-) in relation to Pu 0.042, however. There was no correlation between rs16972959 and anti-keratin antibody in this study. Conclusion the above studies indicate that PKC 尾 gene rs16972959 is not associated with RA genetic susceptibility in Han population. 16972959 was associated with some laboratory indexes.
【作者单位】：安徽医科大学公共卫生学院流行病与卫生统计学系;重大自身免疫性疾病安徽省重点实验室;
【基金】：安徽省自然科学基金(1408085QH179)
【分类号】：R593.22
【正文快照】： (Chin J Dis Control Prev 2017,21(5):478-481)2重大自身免疫性疾病安徽省重点实验室,安徽合肥230032类风湿关节炎(rheumatoid arthritis,RA)是一种慢性炎症性的自身免疫性疾病,主要特征是滑膜关节的进行性破坏,可导致疼痛,关节畸形以及生活质量低下[1-2]。全世界RA的患病率

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