2型糖尿病患者器官脂肪沉积的磁共振定量研究

发布时间：2018-01-28 12:32

本文关键词： 糖尿病型脂质贮积病磁共振成像　出处：《中国医学影像学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的脂毒性在糖尿病及其相关并发症的发展进程中起到至关重要的作用,然而器官脂肪定量的"金标准"为活检及组织化学染色,其均为有创操作并有其自限性,故本研究应用MR 3点式T2~*校正Dixon技术进行体内器官脂肪沉积的无创性定量,并比较糖尿病患者和正常志愿者腹部器官脂肪沉积的差异。资料与方法本研究共招募65例临床诊断为2型糖尿病患者和34例正常受试者。每位受试者均接受3.0 T MR腹部轴位常规平扫及T2~*校正的3点式Dixon序列扫描。比较两组受试者的肝脏、脾脏和胰腺的脂肪分数,分析受试者各器官脂肪沉积与体重指数、年龄等的相关性。结果 2型糖尿病组的肝脏和脾脏脂肪分数分别为(5.4±4.3)%、(3.7±1.4)%,明显高于正常组[(2.9±1.3)%、(3.0±0.9)%],差异有统计学意义(P0.05)。2型糖尿病组的胰腺脂肪分数与正常组差异无统计学意义(P0.05)。99例受试者的肝脏、脾脏和胰腺的脂肪分数与BMI相关(r=0.379、0.305、0.306,P0.05),仅胰腺脂肪分数与年龄存在相关性(r=0.261,P0.05)。结论无创性MR T2~*校正的3点式Dixon技术能够发现糖尿病患者的肝脏及脾脏的异常脂肪沉积,有助于腹部器官脂质沉积的评估。
[Abstract]:Objective Lipotoxicity plays an important role in the development of diabetes mellitus and its related complications. However, the gold standard for organ fat quantification is biopsy and histochemical staining. All of them were invasive and self-limited. Therefore, Mr 3-point T2T * corrected Dixon technique was used for noninvasive quantitative analysis of adipose deposition in vivo. Data and methods A total of 65 patients with type 2 diabetes and 34 normal volunteers were recruited. 3.0. T-Mr axial plain scan and T _ 2 ~ + corrected 3-point Dixon sequence were performed to compare the liver of the two groups. The fat fraction of spleen and pancreas, and the correlation between fat deposition and body mass index, age were analyzed. Results the fat fraction of liver and spleen in type 2 diabetic group was 5.4 卤4.3%. The ratio of 3. 7 卤1. 4 was significantly higher than that of the normal group. [(2. 9 卤1. 3 卤3. 0 卤0. 9%). There was no significant difference in pancreatic fat fraction between type 2 diabetes mellitus group and normal group. The fat fraction of spleen and pancreas was correlated with BMI. Conclusion Non-invasive Mr T2 + corrected three-point Dixon technique can detect abnormal fat deposits in the liver and spleen of diabetic patients, which is helpful for the evaluation of lipid deposition in abdominal organs.
【作者单位】：东南大学医学院;
【分类号】：R445.2;R587.2
【正文快照】： 2型糖尿病是最常见的糖尿病类型[1-2]。研究表明,脂毒性主要促进胰岛素抵抗、活性氧基团和内质网应非脂肪组织的异常脂质沉积可导致器官功能损伤,如激的产生、信号通路的改变以及促炎、促纤维化因子的肝脏脂肪性肝炎和肝硬化[3-5],胰腺β细胞功能障碍[6]释放,上述因素在糖尿病

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