217例2型糖尿病住院患者血糖波动的影响因素

发布时间：2018-01-28 12:55

本文关键词： 血糖波动动态血糖监测型糖尿病平均血糖波动幅度影响因素　出处：《中国医科大学学报》2017年03期 　论文类型：期刊论文

【摘要】：目的分析217例住院2型糖尿病患者血糖波动的影响因素。方法回顾性分析2013年1月至2015年1月于中国医科大学附属第一医院内分泌与代谢病科住院并行动态血糖监测的217例2型糖尿病患者。以平均血糖波动幅度(MAGE)和血糖标准差(SDBG)为血糖波动评估指标。结果分别比较不同性别、年龄、病程、糖化血红蛋白水平、体质量指数(BMI)患者的血糖波动水平,发现女性的MAGE和SDBG显著高于男性(P0.05);不同年龄分组及不同病程的血糖波动水平无统计学差异;随着糖化血红蛋白水平的升高,血糖波动幅度增大(P0.05);随着BMI的升高,血糖波动水平升高(P0.05)。非条件多因素logistic回归分析结果显示,性别(OR=0.67,P=0.02)、糖化血红蛋白(OR=0.8,P=0.02)、舒张压(OR=0.9,P=0.03)、甘油三酯(OR=4.6,P=0.007)、胆固醇(OR=0.6,P=0.007)、高密度脂蛋白(OR=0.09,P=0.006)是2型糖尿病患者血糖波动的影响因素。结论性别、糖化血红蛋白、BMI、血脂与2型糖尿病患者的血糖波动水平有关,而年龄、病程与血糖的波动水平无关。
[Abstract]:Objective to analyze the influencing factors of blood glucose fluctuation in 217 inpatients with type 2 diabetes mellitus. Methods from January 2013 to January 2015, we analyzed retrospectively the endocrine and metabolic diseases department of the first affiliated Hospital of China Medical University. 217 patients with type 2 diabetes mellitus who were hospitalized with dynamic blood glucose monitoring. MAGEand SDBG were the indexes of blood glucose fluctuation. Age, course of disease, glycosylated hemoglobin level, body mass index (BMI) patients' blood sugar fluctuation level, found that the MAGE and SDBG in women were significantly higher than that in men (P 0.05). There was no significant difference in blood glucose fluctuation between different age groups and different course of disease. With the increase of glycosylated hemoglobin, the fluctuation range of blood sugar increased (P 0.05). With the increase of BMI, the fluctuation level of blood glucose increased (P 0.05). Non-conditional multivariate logistic regression analysis showed that there was a significant difference between the two groups (0.67% P 0.02). Glycosylated hemoglobin (ORX) was 0.8m P0. 02G, diastolic blood pressure was 0.9m P0. 03C, triglyceride was 4. 6m P0. 007). The results showed that the changes of blood glucose in patients with type 2 diabetes mellitus were related to the changes of blood glucose in patients with type 2 diabetes mellitus. Conclusion Sex is one of the most important factors affecting blood glucose fluctuation in patients with type 2 diabetes. BMI, blood lipids were related to the fluctuation level of blood glucose in type 2 diabetes mellitus, but age and course of disease were not related to the fluctuation level of blood sugar.
【作者单位】：中国医科大学附属第一医院内分泌与代谢病科内分泌研究所辽宁省内分泌疾病重点实验室;
【分类号】：R587.1
【正文快照】： 糖尿病是由遗传和环境因素共同引起的一组以糖代谢紊乱为主要表现的临床综合征。慢性高血糖为其主要特征。慢性高血糖可分为慢性波动性高血糖和慢性持续性高血糖。有研究[1]表明,相对于持续性高血糖,波动性高血糖更能促进糖尿病慢性并发症的发生和发展。血糖波动通过活化氧

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