细胞色素P450基因多态性对围绝经期妇女潮热易感性的影响

发布时间：2018-01-30 17:26

  本文关键词： 围绝经期 潮热 雌激素 细胞色素P 基因多态性　出处：《第三军医大学学报》2016年14期 　论文类型：期刊论文

【摘要】：目的研究性激素水平及雌激素代谢酶相关基因细胞至色素P450(cytochrome P450,CYP)多态性对围绝经期妇女潮热易感性的影响。方法选取2006年10月至2008年5月西安交通大学第一附属医院体检中心进行健康体检的328名围绝经期妇女进行病例对照研究,将其分为潮热组(n=156)和无潮热组(n=172)。采用放免法测定血清卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)和睾酮(testosterone,T),酶免法测定性激素结合球蛋白(sex hormone binding globulin,SHBG)和硫酸脱氢表雄酮(dehydroepiandrosterone sulfate,DHEA-S)。应用聚合酶链反应-限制性片段长度多态性方法分析两组妇女CYP17 Msp A1Ⅰ、CYP19Rsa I、CYP1A1 Msp I和CYP1B1 Eco57I基因多态性。结果与无潮热组妇女比较,潮热组妇女血清FSH水平增高(P0.01),而E2和SHBG水平降低(P0.05)。CYP1B1 Eco57I基因多态性在潮热组和无潮热组妇女中的分布差异有统计学意义(P0.05);携带CYP1B1 Eco57I基因多态性的妇女潮热发生的风险为未携带妇女的1.25倍(OR=1.25,95%CI:1.03~1.82);中重度潮热发生及潮热持续时间1年的风险分别为未携带妇女的1.28倍和1.35倍。结论血清E2水平降低可能是潮热发生的原因之一。CYP1B1 Eco57I基因多态性增加妇女潮热发生、潮热程度和持续时间的风险。
[Abstract]:Objective to study the level of sex hormone and the cytochrome P450 in cytochrome P450 cells associated with estrogen metabolism enzyme. Cyp). The effect of polymorphism on the predisposition of peri-menopausal women to hot flashes. Methods from October 2006 to May 2008, the physical examination center of the first affiliated Hospital of Xi'an Jiaotong University was selected to conduct physical examination in 328 postmenopausal women. A case-control study was conducted among women. The serum follicle stimulating hormone (FSH) was determined by radioimmunoassay (RIA). Follicle stimulating hormone. FSHG, luteinizing hormone, estradiolone E2) and testosterone testosterone. Hormone binding globulin of sex hormone binding globulin was determined by enzyme immunoassay. Sulfate and dehydroepiandrosterone sulfate dehydroepiandrosterone sulfate. CYP17 Msp A1 鈪，

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