2型糖尿病患者血清25羟维生素D3水平与周围神经病变的相关性

发布时间：2018-01-31 20:32

  本文关键词： 型糖尿病 羟维生素D 周围神经病变　出处：《中国老年学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨2型糖尿病(T2DM)患者血清25羟维生素D3〔25-(OH)D3〕水平与周围神经病变(DPN)的相关性。方法选择2015年1~10月在该院就诊的T2DM患者124例,其中64例合并DPN的患者为观察组,另60例单纯T2DM患者为对照组,比较两组实验室指标水平及血清25-(OH)D3相关指标情况,分析血清25-(OH)D3与DPN的相关性。结果两组血肌酐、甲状旁腺激素(PTH)、血钙、血磷水平比较无显著差异(P0.05)。观察组的血清25-(OH)D3水平显著低于对照组,25-(OH)D3含量20 ng/ml的比例显著高于对照组(P0.05)。Pearson相关分析发现,血清25-(OH)D3与DPN的发病呈负相关。结论 T2DM合并DPN的患者血清25-(OH)D3水平显著低于单纯T2DM患者,且血清25-(OH)D3与DNP之间呈负相关联系。
[Abstract]:Objective to study the relationship between the serum 25 hydroxyvitamin D 325-OHD3 level and peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM). Methods 124 cases of T2DM were selected from 2015 to October. 64 patients with DPN were treated as observation group and 60 patients with simple T2DM as control group. The laboratory indexes and serum 25-OHH D3 related indexes were compared between the two groups. Results the serum creatinine, parathyroid hormone (PTH) and serum calcium in the two groups were analyzed. There was no significant difference in serum phosphorus levels between the two groups (P 0.05). The serum levels of 25-OHN D3 in the observation group were significantly lower than those in the control group. The percentage of OHN D3 content in the control group with 20 ng/ml was significantly higher than that in the control group (P0.05N. Pearson correlation analysis). Conclusion the serum level of 25-OHH D3 in patients with T2DM with DPN was significantly lower than that in patients with T2DM alone. There was a negative correlation between serum 25-OHN D 3 and DNP.
【作者单位】： 北京老年医院内分泌科;
【分类号】：R587.2
【正文快照】： 糖尿病周围神经病变(DPN)在2型糖尿病(T2DM)患者中的发病率高达30%~70%〔1〕。当前不能明确DPN发病的具体机制,仅认为DPN可能与糖尿病患者体内代谢异常及氧化应激等因素有关。有报道〔2〕称25羟维生素D3〔25-(OH)D3〕可能与T2DM患者合并DPN的发病具有一定联系。本文旨在分析T2，

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