青年原发高尿酸血症氧化应激与炎症的关系研究

发布时间：2018-02-01 02:53

本文关键词： 青年患者高尿酸血症氧化应激炎症反应　出处：《中国现代医学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的分析青年原发高尿酸血症氧化应激与炎症的关系。方法选取青年原发高尿酸血症患者64例为高尿酸(HUA)组,健康体检者60例为对照组,检测血清丙二醛(MDA)、超氧化物歧化酶(SOD)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平。结果 HUA组MDA、IL-6、TNF-α高于对照组,SOD低于对照组(P0.05);血清尿酸水平与MDA、IL-6、TNF-α呈正相关,与SOD呈负相关(P0.05);MDA与IL-6、TNF-α呈正相关(P0.05),SOD与IL-6、TNF-α呈负相关(P0.05);尿酸、MDA及SOD是IL-6、TNF-α的影响因素(P0.05)。结论青年原发高尿酸血症患者体内呈氧化应激及微炎症状态,而患者体内炎症应答可能与高尿酸引起的氧化应激反应有关。
[Abstract]:Objective to analyze the relationship between oxidative stress and inflammation in young patients with primary hyperuricemia. Methods 64 young patients with primary hyperuricemia were selected as hyperuricemia group and 60 healthy persons as control group. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-6 (IL-6) and tumor necrosis factor 伪 (TNF- 伪) were measured. The level of TNF- 伪 was higher than that of control group (P 0.05). Serum uric acid level was positively correlated with IL-6 TNF- 伪 and negatively correlated with SOD (P 0.05). There was a positive correlation between MDA and IL-6 TNF- 伪. There was a negative correlation between MDA and IL-6TNF- 伪. Malondialdehyde (MDA) and SOD were the influencing factors of IL-6 TNF- 伪. Conclusion the young patients with primary hyperuricemia have oxidative stress and microinflammation. The inflammatory response in patients may be related to oxidative stress induced by high uric acid.
【作者单位】：四川省遂宁市中心医院检验科;
【基金】：四川省重点专科建设基金[No:(2015)328] 四川省卫生和计划生育委员会科研课题(No:17PJ067)
【分类号】：R589.7
【正文快照】： 随着人类生活水平提高及膳食结构改变,加之遗传、环境因素的影响,高尿酸血症的发病率在全球范围内呈逐步升高的趋势[1]。流行病学调查显示,高尿酸血症是心血管疾病、脑卒中发病及死亡的独立α呈正相关(P0.05),SOD与IL-6、TNF-α呈负相关(P0.05);尿酸、MDA及SOD是IL-6、TNF-

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