糖尿病周围神经病变治疗药物使用合理性评价

发布时间：2018-02-01 13:53

本文关键词： 糖尿病周围神经病变药物治疗合理性适宜性有效性安全性　出处：《中国新药杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:通过调研某三甲医院内分泌科住院的糖尿病患者使用糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)治疗药物的情况,分析其用药合理性,为临床合理用药提供参考。方法:调研2015年5月1日—2016年3月31日期间住院的糖尿病患者使用DPN治疗药物的情况,根据相关指南、药品说明书及文献,评价其用药的适宜性,包括适应证、用法用量、溶媒配伍及相互作用等方面;根据多伦多临床评分系统(Toronto Clinical Scoring System,TCSS),评估患者入院及出院时是否存在周围神经病变及其严重程度,评价DPN治疗药物的短期疗效;通过观察患者院内不良反应的发生情况,评价短期用药的安全性。结果:本研究共纳入302例患者,其中存在DPN的患者所占比例是76.16%。在这些患者中,使用DPN治疗药物的比例是66.09%。DPN治疗药物无适应证用药及用法用量存在问题的比例为16.36%。使用较多的2组治疗方案"硫辛酸注射液+注射用腺苷钴胺"、"注射用腺苷钴胺"对DPN有效,2组患者TCSS出院评分小于入院评分,差异具有统计学意义。院内使用DPN治疗药物的患者仅发生2例不良反应。结论:DPN治疗药物在内分泌科使用广泛且较为合理,使用的适宜性有待提高,有一定疗效,按说明书推荐方法使用安全性较好。
[Abstract]:Objective: to investigate the use of diabetic peripheral neuropathy (peripheral neuropathy) in patients with diabetes mellitus in the Department of Endocrinology in a third Grade A Hospital. DPN was used to treat the drug and its rationality was analyzed. Methods: to investigate the use of DPN in diabetic patients from May 1st 2015 to March 31st 2016, according to the relevant guidelines. To evaluate the suitability of drug use, including indications, usage dosage, solvent compatibility and interaction, etc. According to the Toronto Clinical Scoring system. To evaluate the presence and severity of peripheral neuropathy at admission and discharge, and to evaluate the short-term efficacy of DPN. The safety of short-term medication was evaluated by observing the occurrence of adverse reactions in hospital. Results: 302 patients were included in this study. The proportion of patients with DPN was 76.16. The proportion of drugs treated with DPN was 66.09%. The proportion of unindications and dosage of DPN treatment was 16.3636%. Lipoic acid injection for injection of adenosine Cobalamin ". The TCSS discharge score of patients in group 2 of "adenosine cobalamin for injection" in DPN effective group was lower than that in admission group. The difference was statistically significant. There were only 2 adverse reactions in patients with DPN in hospital. Conclusion the use of DPN in endocrine department is extensive and reasonable, and the suitability of using it needs to be improved. Has certain curative effect, according to the instruction to recommend the method to use the safety to be good.
【作者单位】：北京大学药学院;北京医院国家老年医学中心;
【分类号】：R587.2
【正文快照】： 糖尿病周围神经病变(diabetic peripheral neu-ropathy,DPN)是糖尿病最常见的慢性并发症之一,是指在排除其他原因的情况下,糖尿病患者出现周围神经功能障碍相关的症状和/或体征[1]。DPN起病通常较隐匿,可导致足部溃疡的形成和肌肉、关节疾病的发生,是导致非创伤性截肢的主要原

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