新疆维吾尔族、哈萨克族农村居民高同型半胱氨酸血症流行特点及与相关疾病的关系

发布时间：2018-02-03 23:40

本文关键词： 哈萨克族维吾尔族同型半胱氨酸 H型高血压患病率影响因素　出处：《石河子大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的通过现况调查掌握新疆哈萨克族和维吾尔族农村居民高同型半胱氨酸血症(Hyperhomocysteinemia,HHcy)患病水平及流行特征,对比分析两民族HHcy相关影响因素,探讨HHcy与高血压、糖尿病之间的关系,为进一步开展同型半胱氨酸(Homocysteine,Hcy)的研究提供基础数据,为心脑血管疾病的发病机制及预防控制提供相关依据。方法采用整群随机抽样的方法,2009年-2010年分别在新疆哈萨克族聚居区伊犁新源县那拉提镇和维吾尔族聚居区喀什伽师县江巴孜乡按照区域分层,以村为单位随机抽取6和12个自然村,通过一对一入户调查村中25岁及以上常住居民,收集问卷信息和资料,体检并采集血标本。按性别和年龄分层,在哈萨克族3390人和维吾尔族3821人样本中分别随机抽取1003人、1177人,共计2180人作为研究对象,检测血清Hcy及生化指标。运用SPSS20.0统计软件,正态分布的计量资料用x±s描述,血清Hcy水平呈正偏态分布,经对数(lg10)转换后近似正态分布,以几何均数(G)和相应的95%可信区间(95%CI)代表血清Hcy平均水平。两组均值比较采用独立样本t检验,多组均值比较采用单因素方差分析。计数资料采用百分率表示,组间率采用χ2及χ2趋势检验进行比较;单、多因素及与疾病的关系使用非条件Logistic回归进行分析并计算比值比及其95%可信区间。P0.05(双侧检验)认为差异有统计学意义。结果1.哈萨克族与维吾尔族农村居民Hcy水平分别为13.3(9.2~19.4)、13.7(8.8~21.4)μmol/L;HHcy患病率分别为80.0%和78.2%,标化患病率哈萨克族为81.9%高于维吾尔族的76.6%,差异有统计学意义(χ2=6.391,P=0.001)。男性HHcy患病率分别为93.5%和90.8%,35~岁组,HHcy患病率哈萨克族男性高于维吾尔族男性(P0.05),女性HHcy患病率分别为69.6%和64.4%,其中35~、55~岁组哈萨克族HHcy患病率高于维吾尔族(P均0.05)。2.两民族HHcy患病率男性高于女性,H型高血压患病率男性亦高于女性(P均0.05)。3.两民族人群HHcy患病率有随年龄增长而升高的趋势(P0.01)。4.哈萨克族人群HHcy的危险因素为年龄、男性;维吾尔族人群HHcy的危险因素有年龄、男性和高血压。5.哈萨克族农村居民高血压和糖尿病总患病率分别为40.1%、10.0%,维吾尔族居民分别为34.7%、4.5%。两民族两种慢性病患病率均随Hcy水平的增加而升高(P均0.001)。结论1.新疆哈萨克族和维吾尔族农村居民Hcy水平、HHcy、H型高血压患病率均处于全国较高水平。2.哈萨克族和维吾尔族农村居民HHcy患病率男性高于女性,两民族HHcy患病率均有随年龄增长而升高的趋势。3.哈萨克族人群HHcy的危险因素为年龄、男性;维吾尔族人群HHcy的危险因素有年龄、男性和高血压。4.哈萨克族和维吾尔族农村居民糖尿病、高血压患病率有随Hcy水平增加而升高的趋势;HHcy可能与两民族的两种慢性病相关。
[Abstract]:Objective to investigate the hyperhomocysteinemia in Kazak and Uygur rural residents in Xinjiang. The prevalence level and epidemic characteristics of Hcy were compared and analyzed in order to explore the relationship between HHcy and hypertension and diabetes mellitus. To provide basic data for further research on homocysteine homocysteine homocysteine (Hcy). Methods Cluster random sampling was used to provide relevant basis for the pathogenesis and prevention and control of cardiovascular and cerebrovascular diseases. 2009 to 2010 in Xinjiang Kazak settlement area Yili Xinyuan County Nalati Town and Uygur area Kashgar Jiashi County Jiangbazi according to the regional stratification. 6 and 12 natural villages were randomly selected from each village. The residents aged 25 and above were investigated by one-to-one household survey, questionnaire information and data were collected, and blood samples were collected and stratified according to sex and age. Among the 3390 Kazakh and 3821 Uygur samples, 1,167 were randomly selected from 1003 people, a total of 2180 people were selected as the subjects of the study. The serum Hcy and biochemical indexes were detected. The normal distribution data were described by x 卤s and the serum Hcy level was positively skewed by using SPSS20.0 statistical software. The normal distribution is approximately transformed by logarithmic lg10). The average level of serum Hcy was represented by the geometric mean (G) and the corresponding 95% CI (95 CI). The mean values of the two groups were compared by independent sample t-test. Single factor analysis of variance was used to compare the mean values of multiple groups. The counting data were expressed as percentages, and the rates among groups were compared by 蠂 ~ 2 and 蠂 ~ 2 trend tests. Single. Multivariate and disease-related analysis using non-conditional Logistic regression analysis and calculation of the ratio ratio and its 95% confidence interval. P0.05 (bilateral test). The difference was statistically significant. Results 1. The Hcy level of Kazak and Uygur rural residents was 13.3n-2 (19.4). 13.7 渭 mol / L, 8.8 渭 mol / L, 21.4 渭 mol / L; The prevalence of HHcy was 80.0% and 78.2, respectively. The standardized prevalence rate of Kazak was higher than that of Uygur (81.9%), and the difference was statistically significant (蠂 ~ 2 / 6.391). The prevalence rate of HHcy in male was 93.5% and 90.8% respectively. The prevalence rate of Hcy in Kazak nationality was higher than that in Uygur male (P 0.05). The prevalence of HHcy in females was 69.6% and 64.4, respectively. The prevalence of HHcy in Kazak was higher than that in Uygur (P = 0.050.2.The prevalence of HHcy in males was higher than that in females). The prevalence rate of H type hypertension in males was also higher than that in females (P < 0.05). The prevalence rate of HHcy in the two ethnic groups increased with age (P 0.01). Age is the risk factor for HHcy in Kazakh population. Male; The risk factors of HHcy in Uygur population were age, male and hypertension. 5. The total prevalence of hypertension and diabetes were 40.1% and 10.0% in Kazakh rural residents, respectively. Uygur residents were 34.7%. 4.5.The prevalence of chronic diseases in both nationalities increased with the increase of Hcy level (P 0.001). Conclusion 1.The Hcy level of Kazak and Uygur rural residents in Xinjiang is significant. The prevalence of H type hypertension was at a higher level in China. 2. The prevalence of HHcy in Kazakh and Uygur rural residents was higher than that in females. The prevalence of HHcy increased with age. 3. The risk factors of HHcy in Kazakh population were age, male; The risk factors of HHcy in Uygur population were age, male and hypertension .4.The prevalence of hypertension increased with the increase of Hcy level in Kazakh and Uygur rural residents. HHcy may be associated with two chronic diseases in both peoples.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R589

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