2型糖尿病视网膜血管改变研究

发布时间：2018-02-08 13:02

  本文关键词： 视网膜病变 糖尿病 视网膜动脉 视网膜静脉 血糖　出处：《中国现代医学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的探讨2型糖尿病T2(DM)视网膜动、静脉直径变化的影响因素。方法选取2015年6月-2015年12月该院收治的105例T2DM患者为研究对象,对所有患者的右眼进行彩色眼底照相,由系统半自动测量距离视乳头中心1.0~1.5 PD范围内的动、静脉直径,采用多元线性回归方法来分析其与性别、年龄、高血压、空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、总三酰甘油(TG)、总胆固醇(TC)、DM病程及视网膜病变(DR)分期等的相关性。结果全部患者的视网膜动脉、静脉的平均直径分别为(52.07±7.89)和(85.92±8.87)μm。有47例(44.8%)合并DR。合并高血压、DM病程≥10年的视网膜动脉直径缩小,差异均有统计学意义(P0.05)。年龄65岁、FBG≥10.5 mmol/L、Hb A1c≥7.0%及DM病程≥10年的视网膜静脉直径增大,差异有统计学意义(P0.05)。随着DM分期的进展,视网膜动脉直径逐渐缩小,静脉直径逐渐增大,差异有统计学意义(P0.05)。多元线性回归结果表明视网膜动脉直径与年龄(b=-0.236,P0.05)、DM病程(b=-2.230,P0.05)和DR分期(b=-2.017,P0.05)存在线性关系。视网膜静脉直径与FBG(b=1.036,P0.05)、DR分期(b=2.256,P0.05)等存在线性关系。结论合并DR的DM患者容易出现视网膜动脉缩窄与静脉扩张现象,且随着DR病情的加重,视网膜动脉直径越小,静脉直径越大。
[Abstract]:Objective to investigate the factors influencing the diameter of retinal artery and vein in type 2 diabetes mellitus (T2DM). Methods 105 cases of T2DM treated in our hospital from June 2015 to December 2015 were selected and their right eyes were examined by color fundus photography. The diameter of artery and vein in the range of 1.0 ~ 1.5 PD distance from the center of optic papilla was measured semi-automatically by the system. Multivariate linear regression method was used to analyze its relationship with sex, age, hypertension. The correlation of FBGG, HbA1cG, TGG, TCU DM course and DRN stage of retinopathy were observed. Results the retinal artery was found in all patients. The mean diameters of vein were 52.07 卤7.89) and 85.92 卤8.87 渭 m respectively. The diameter of retinal vein increased in 65 years old with FBG 鈮，

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