太原地区健康男性腰椎骨密度与血脂代谢的相关性及意义

发布时间：2018-02-12 23:04

本文关键词： BMD 血脂四项 OP 年龄 BMI　出处：《山西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本课题对来我院体检的健康男性人群进行腰椎(L1-L4)骨密度(BMD)、血脂四项包括血清总胆固醇(Total Cholesterol,TC)、甘油三酯(Triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)的测定,并探讨BMD与年龄(Age)、体重指数(Body mass index,BMI)和血脂四项的相关性。方法:1.一般资料的收集:通过问卷调查填写研究对象的Age、既往史、现病史、服用药物情况,并测量身高,体重,计算出BMI,根据本课题需求筛选出符合要求的251例健康男性体检者。2.BMD检测:用美国Hologic公司生产的型号为Discovery-Wi型数字化双能X线骨密度仪(DXA)来对BMD进行检测,每日开机后,先用脊骨模型执行一遍系统测试,系统将运行自动质量控制(Auto QC)测试。质控通过后方能进行人体BMD的检测,测定部位与方法:将被检者性别、出生年月日、身高、体重输入计算机,要求被检者去除身上钥匙,拉链等金属物品,以免对结果有影响,被检者平躺于测量床上,用DXA测量其正位腰椎(L1-4)的BMD,为避免操作误差,BMD检测均由同一个专业技术人员来完成,由微机控制仪器,分析后结果自动生成。3.血脂四项检测:被检者禁食禁水8 h以上,于次日清晨8点至10点之间采集静脉血5 m L,离心后并分离出血清,于4 h之内完成血脂四项的检测,采用由深圳迈瑞公司生产的全自动生化分析仪器检测,试剂由山西德盟贸易有限公司供应,每批样本检测前,使用检测项目所配套的质控品完成该项目的质量控制检测。结果:1.骨质疏松(osteoporosis,OP)组的平均年龄、TC,LDL-C较非OP组高,差异无统计学意义(P0.05)。而OP的BMI却较非OP组低(23.17±3.40 kg/m2 vs 25.30±3.37 kg/m2),差异有统计学意义(P0.05)。2.L1-4BMD与BMI(r=0.314 P0.05)正相关,与TC(r=-0.181 P0.05),HDL-C(r=-0.141 P0.05)呈负相关;控制年龄和BMI这两个因素后,对BMD与TG、TC、HDL-C和LDL-C进行偏相关分析:L1-4BMD与TC(r=-0.197 P0.05)仍呈负相关,与TG(r=-0.145 P0.05),LDL-C(r=-0.148 P0.05)呈负相关。3.对OP相关危险因素进行Logistic回归分析:以年龄、BMI、TC、TG、LDL-C、HDL-C为自变量,以OP为因变量来进行回归分析。结果显示,在控制其他变量的影响时,男性BMI是OP的影响因素,且BMI(回归系数B=-0.612,P0.05)是保护性因素。结论:1.男性BMI的适当增加可能会降低OP发生的危险性。2.对长期高血脂症的病人积极的进行降血脂治疗可能会减少OP发病的风险。
[Abstract]:Objective: to measure the bone mineral density (BMD) of lumbar vertebrae (L1-L4), total cholesterol total Cholesterolus (TCN), triglyceride triglyceride (TGG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and high density lipoprotein cholesterol (HDL-C) in healthy male subjects in our hospital. To explore the correlation between BMD and age, body mass index (BMI) and blood lipids. Methods 1. Collecting general data: filling out the data of age, past history, medical history, taking drugs, measuring height and weight by questionnaire. Calculate BMI and screen out 251 healthy male examiners according to the demand of this subject. 2.BMD test: use Discovery-Wi type digital dual-energy X-ray absorptiometry made by Hologic Company in the United States to detect BMD. After daily booting up, The system will run automatic quality control auto QC test. Quality control can be used to detect human BMD through the rear. The location and method: gender, date of birth, date of birth, height, etc. The body weight was fed into the computer and the subjects were asked to remove metal items such as keys and zippers so as not to affect the results. The subjects lay flat on the measuring bed. In order to avoid the operating error, the detection of L1-4 (L1-4) of the lumbar vertebrae was carried out by the same professional and technical personnel. The results were automatically generated by the microcomputer controlled instrument. The results of the analysis were automatically generated by .3.The four tests of blood lipids were as follows: the subjects fasted for more than 8 hours and were banned from drinking and water for more than 8 hours. The venous blood was collected from 8: 00 am to 10:00 the next day. After centrifugation, the serum was separated, and the four items of blood lipid were detected within 4 hours. The blood lipid was detected by the automatic biochemical analysis instrument produced by Shenzhen Mayrui Company. The reagents were supplied by Shanxi Daimeng Trading Co., Ltd. Before each batch of samples were tested, the quality control products of the test items were used to complete the quality control tests of the project. Results: 1. The average age of the osteoporosis osteoporosis OPO group was higher than that of the non-op group. The BMI of op was 23.17 卤3.40 kg/m2 vs 25.30 卤3.37 kg 路m ~ 2 路m ~ (2). There was a positive correlation between BMI(r=0.314 P0.05 and 2.L1-4BMD, and a negative correlation between TC(r=-0.181 P0.05 and HDL-Cr-0.141 (0.05). The partial correlation analysis between BMD and TGT-TGL-HDL-C and LDL-C was that: L1-4BMD was still negatively correlated with TC(r=-0.197 P0.05, and it was negatively correlated with TG(r=-0.145 P0.05LDL-Cnr-0.148 P0.05. Logistic regression analysis was carried out on the related risk factors of op: the age of BMITTCTGL-LDCh HDL-C was taken as independent variable and op as dependent variable. The results showed that, Male BMI is a factor in op when controlling for the effects of other variables. BMI (regression coefficient BU -0.612 P0.05) is a protective factor. Conclusion: 1. The risk of op may be reduced by increasing male BMI. 2. The risk of op may be reduced by active treatment for long-term hyperlipidemia patients.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R580

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