更年期女性胆固醇水平调查与影响因素分析

发布时间：2018-02-15 07:19

  本文关键词： 绝经 总胆固醇(TC) 低密度脂蛋白胆固醇(LDL-C) 性激素 影响因素　出处：《中华生殖与避孕杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的研究胆固醇代谢与绝经的关联和可能的影响因素。方法对杭州市拱墅区963例40~60岁女性进行横断面调查,收集其月经史及其他临床资料,填写改良Kupperman更年期症状量表(mKMI),检测血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_2)水平。收集参与者教育程度、婚姻状态、职业状态、收入、居住地等社会人口资料。研究不同绝经状态女性胆固醇水平及高胆固醇血症、LDL-C升高的发生率,并分析年龄、绝经状态、FSH、E_2、社会人口等因素对血清胆固醇的影响。结果963例参与者平均年龄(51.0±5.6)岁,其中绝经前期302例(31.4%),围绝经期197例(20.5%),绝经后期464例(48.2%),绝经后参与者的平均绝经年龄(49.9±3.8)岁。在所有参与者中,绝经前期mKMI总分(6.36±6.43)显著低于围绝经期(10.30±7.88)和绝经后期(10.35±7.97)(P0.001)。绝经前后平均TC、LDL-C水平呈显著上升趋势,FSH、LH水平呈上升趋势,E_2水平呈下降趋势(P0.001)。所有参与者中高胆固醇血症比例为13.3%,LDL-C升高比例为15.0%,从绝经前期过渡到围绝经期、绝经后期的过程中,高胆固醇血症及LDL-C升高的发生率显著上升(P0.001)。Logistic多元回归分析表明FSH≥40IU/L是发生高胆固醇血症和LDL-C升高的危险因素(OR=2.821,95%CI=1.429~5.569,P=0.003;OR=2.587,95%CI=1.356~4.937,P=0.004),调整FSH水平后,年龄、绝经状态、E_2水平、社会人口因素与发生高胆固醇血症和LDL-C升高均无显著关联(P0.05)。结论相比绝经前期,围绝经期和绝经后女性平均TC、LDL-C上升,胆固醇水平升高的发生率增加,FSH水平升高可能是胆固醇代谢紊乱的内在机制,降低FSH水平可作为绝经激素补充治疗的目标和疗效指标。
[Abstract]:Objective to study the relationship between cholesterol metabolism and menopause and its possible influencing factors. Methods 963 women aged 4060 years old in Gongshu District of Hangzhou City were investigated cross-sectional and their menstrual history and other clinical data were collected. Filling out the modified Kupperman climacteric symptom scale (MKMIA), measuring serum total cholesterol, low density lipoprotein cholesterol (LDL-C), follicle stimulating hormone (FSH), luteinizing hormone (LHH), estradiol (E2). The educational level, marital status, professional status, income of participants were collected. Social and demographic data such as residence. To study the incidence of LDL-C increase in women with different menopausal status and hypercholesterolemia, and to analyze the age, The influence of social and demographic factors on serum cholesterol. Results the average age of 963 participants was 51.0 卤5.6 years old. Of these, 302 were premenopausal, 197 were peri-menopausal, and 464 were postmenopausal. The mean menopausal age of postmenopausal participants was 49.9 卤3.8 years. The total score of mKMI in premenopausal period (6.36 卤6.43) was significantly lower than that in peri-menopausal period (10.30 卤7.88) and postmenopausal period (10.35 卤7.97) (P 0.001). The average level of mKMI LDL-C increased significantly before and after menopause. The ratio of LDL-C increase was 15.0%, from pre-menopausal period to peri-menopausal period, During the postmenopausal period, the incidence of hypercholesterolemia and LDL-C increased significantly. Logistic multiple regression analysis showed that FSH 鈮，

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