库欣病患者脑功能改变及任务态功能磁共振成像研究

发布时间：2018-02-15 16:00

本文关键词： 库欣病精神障碍脑功能任务态功能磁共振成像　出处：《解放军医学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的采用情绪评估量表和任务态功能磁共振成像(Task f MRI)技术,分析库欣病(CD)患者脑功能改变及其与精神症状的关系。方法收集2015年11月-2016年11月在解放军总医院内分泌科住院诊断为库欣病的8例患者,并选取21名年龄、性别和受教育程度相匹配的健康人作为对照组,对其进行Zung抑郁自评量表(SDS)、Zung焦虑自评量表(SAS)、正性负性情绪量表(PANAS)和库欣生活质量量表(Cushing QOL)的评估,并行Task f MRI检查。结果与对照组相比,CD组患者均存在抑郁、焦虑状态,正性情绪评分低,而负性情绪评分较高。Task f MRI结果显示,观看正性图片时CD组左侧小脑和右侧中央后回激活程度较对照组减弱,左侧小脑激活程度与16:00点促肾上腺皮质激素(ACTH)水平呈正相关,右侧中央后回激活程度与尿游离皮质醇(UFC)水平呈正相关;观看负性图片时左侧小脑、双侧海马旁回和左侧额下回激活程度较对照组明显减弱,左侧小脑激活程度与0:00点皮质醇水平和焦虑量表评分呈负相关,与UFC水平呈正相关;观看中性图片时左侧小脑和左侧海马旁回激活程度较对照组减弱。结论 CD患者脑功能受损,会出现抑郁、焦虑等精神障碍,通过Task f MRI技术可发现左侧额下回、右侧中央后回、双侧海马旁回和左侧小脑激活程度减弱与之相关。
[Abstract]:Objective to use the emotion assessment scale and task-based functional magnetic resonance imaging (fMRI) technique. The changes of brain function and their relationship with mental symptoms in patients with Cushing's disease were analyzed. Methods eight patients with Cushing's disease were collected from November 2015 to November 2016 in the Department of Endocrinology, General Hospital of PLA, and 21 patients were selected as their age. Healthy subjects matched with sex and education were assessed with Zung self-rating depression scale (Zung) and Cushing's quality of life scale (Cushing QOL) by using Zung self-rating anxiety scale (SAS), positive and negative emotion scale (PANASS) and Cushing's quality of Life scale (Cushing QOL). Results compared with the control group, the patients in the CD group had depression, anxiety, lower positive emotion score, and higher negative emotion score. The results showed that the negative emotion score was higher than that in the control group, and the negative emotion score was higher than that in the control group. The activation degree of left cerebellum and right posterior central gyrus in CD group was lower than that in control group, and the activation degree of left cerebellum was positively correlated with the level of ACTH at 16:00. The degree of activation of the right posterior central gyrus was positively correlated with the level of urinary free cortisol UFC, and the activation degree of the left cerebellum, bilateral pariprahippocampal gyrus and left inferior frontal gyrus was significantly lower than that of the control group. The activation degree of left cerebellum was negatively correlated with the level of cortisol at 0:00 and anxiety scale, but positively correlated with the level of UFC. The activation degree of left cerebellum and left parahippocampal gyrus was weaker than that of control group. Conclusion the left inferior frontal gyrus can be found by Task f MRI technique. The decrease in the activation of the right posterior central gyrus, bilateral parahippocampal gyrus and left cerebellum was associated with the decrease in the degree of activation.
【作者单位】：解放军总医院内分泌科全军内分泌代谢重点实验室;解放军总医院放射诊断科;郑州大学物理工程学院;中国科学院高能物理研究所、核技术应用研究中心;中国科学院高能物理研究所、核技术应用研究中心北京市射线成像技术与装备研究中心;
【基金】：国家自然科学基金(81171319) 解放军总医院“百病妙诀”扶植项目(MJ201401);解放军总医院“百位名医”项目(MY201401)~~
【分类号】：R586.2

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