中青年非妊娠女性碘营养状态与甲状腺疾病及功能的关系研究

发布时间：2018-02-15 20:53

本文关键词： 甲状腺疾病碘甲状腺功能亢进症甲状腺功能减退症　出处：《中国全科医学》2017年S2期 　论文类型：期刊论文

【摘要】：目的调查胜利油田中青年非妊娠女性碘营养状态和甲状腺疾病,并分析二者的相互关系。方法以2012—2013年胜利油田中心医院体检的胜利油田中青年非妊娠女性为调查对象。进行问卷调查、体格检查,并进行尿碘检测、甲状腺功能、甲状腺相关抗体和甲状腺B超检查。结果调查总人群尿碘中位数为113.4μg/L。其中甲状腺疾病组413人,占44.36%,尿碘中位数112.7μg/L,与正常组比较差异无统计学意义(P0.05);不同甲状腺疾病组尿碘水平比较,差异无统计学意义(P0.05),不同尿碘水平者三碘甲状腺原氨酸(T_3)、甲状腺素(T_4)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺激素(TSH)水平比较,差异均无统计学意义(P0.05)。甲状腺过氧化物酶抗体(TPOAb)阳性组及甲状腺球蛋白抗体(Tg Ab)阳性组尿碘水平均明显高于TPOAb阴性组及TgAb阴性组(P0.05)。多因素Logistic回归分析结果显示,年龄[OR=1.040,95%CI(1.009,1.071)]及甲状腺抗体阳性[OR=5.680,95%CI(3.864,8.349)]为中青年非妊娠女性甲状腺疾病及功能异常的危险因素(P0.05),而甲状腺疾病发病与尿碘水平[OR=0.985,95%CI(0.822,1.182)]无相关性(P0.05)。结论胜利油田中青年非妊娠女性碘摄入充足,该人群甲状腺疾病及功能异常可能与年龄及甲状腺抗体阳性有关,与碘营养状态无关。
[Abstract]:Objective to investigate iodine nutritional status and thyroid diseases of young and middle-aged non-pregnant women in Shengli Oilfield. Methods the young non-pregnant women in Shengli Oilfield from 2012-2013 were investigated by questionnaire, physical examination, urine iodine test and thyroid function. Results the median urinary iodine was 113.4 渭 g / L in the total population. The median of urinary iodine was 112.7 渭 g / L, which was not significantly different from that of the normal group (P 0.05), and the urinary iodine level of different thyroid diseases was higher than that of the normal group (P < 0.05). There was no significant difference (P 0.05). The levels of triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH) in patients with different urinary iodine levels were compared. There was no significant difference in urinary iodine levels between the two groups. The levels of urinary iodine in the positive group and the positive group were significantly higher than those in the TPOAb negative group and the TgAb negative group (P 0.05). The results of multivariate Logistic regression analysis showed that the urinary iodine level of the positive group was significantly higher than that of the TgAb negative group. Age [ORV 1.040 ~ 95CII 1.009 + 1.071] and thyroid antibody positive (OR5.68095) were the risk factors of thyroid disease and abnormal function in young and middle-aged non-pregnant women (P 0.05), but there was no correlation between the incidence of thyroid disease and urinary iodine level [OR0.98595CI0.822221.182]. Conclusion the iodine intake of young and middle-aged non-pregnant women in Shengli Oilfield is adequate, and there is no correlation between the incidence of thyroid disease and urinary iodine level (OR0.98595CI0.8221.182). Conclusion the iodine intake of young and middle-aged non-pregnant women in Shengli oil field is adequate, and there is no significant correlation between the incidence of thyroid disease and urinary iodine level (OR0.98595CI0.8221.182). Thyroid disease and abnormal function may be related to age and thyroid antibody positive, but not to iodine nutritional status.
【作者单位】：胜利油田中心医院;
【分类号】：R581

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