冠心病合并糖尿病患者血清CARP水平与冠脉病变关系的研究

发布时间：2018-02-16 03:39

本文关键词： 冠心病糖尿病心肌锚定重复蛋白 Gensini评分糖化血红蛋白　出处：《天津医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：目的:探讨冠心病合并糖尿病患者血清心肌锚定重复蛋白(CARP)水平和冠脉病变的关系。方法:选择住院并接受冠脉造影的患者147例,其中正常对照组(A组)33例,单纯冠心病组(B组)51例,冠心病合并糖尿病组(C组)63例,测定血清CARP、糖化血红蛋白(Hb A1c)水平,冠脉造影计算Gensini评分,探究CARP与它们的相关性。结果:冠心病合并糖尿病组血清CARP水平(24.39±8.31)较单纯冠心病组(14.31±7.77)及对照组(7.90±4.29)明显升高,差异具有统计学意义(P0.05,P0.01);单纯冠心病组(r=0.670,P0.01)及冠心病合并糖尿病组(r=0.732,P0.01)血清CARP水平与Gensini评分均呈正相关;冠心病合并糖尿病组血清CARP水平与HbA1c(r=0.590,P0.05)呈正相关。结论:(1)血清CARP有望成为冠心病合并糖尿病患者冠脉病变严重程度的新型预测标志物。(2)冠心病合并糖尿病患者血清CARP水平与HbAlc呈正相关。
[Abstract]:Objective: to investigate the relationship between serum myocardial anchored repeat protein (CARP) level and coronary artery disease in patients with coronary heart disease and diabetes mellitus. There were 51 patients in group B and 63 patients in group C of coronary heart disease complicated with diabetes mellitus. The serum levels of CARPand HbA1cwere measured. The Gensini score was calculated by coronary angiography. Results: the serum CARP level in CHD with diabetes mellitus was 24.39 卤8.31), which was significantly higher than that in coronary heart disease group (14.31 卤7.77) and control group (7.90 卤4.29). There was a positive correlation between the serum CARP level and the Gensini score in the coronary heart disease group (P 0.05) and the coronary heart disease (CHD) group (P 0.01) and the coronary heart disease (CHD) group with diabetes mellitus (P 0.01). There was a positive correlation between serum CARP level and HBA _ 1cr ~ (0.590) P _ (0.05) in coronary heart disease with diabetes mellitus. Conclusion the serum CARP may be a new marker for predicting the severity of coronary artery disease in patients with coronary heart disease and diabetes mellitus. The level of CARP was positively correlated with HbAlc.
【作者单位】：天津医科大学第二医院心脏科;
【分类号】：R541.4;R587.1

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