老年2型糖尿病合并脑梗死患者血清网膜素1、脂联素水平变化及意义

发布时间：2018-02-16 04:21

本文关键词： 型糖尿病脑梗死网膜素脂联素老年人　出处：《山东医药》2017年29期 　论文类型：期刊论文

【摘要】：目的观察老年2型糖尿病合并脑梗死患者血清网膜素1、脂联素水平变化,并探讨其临床意义。方法选取2型糖尿病合并脑梗死患者50例(A组)、单纯2型糖尿病患者50例(B组)、体检健康者50例(C组)。收集各组临床资料,采用酶联免疫吸附法测定血清网膜素1、脂联素水平。采用直线相关分析血清网膜素1、脂联素与血糖、血压、血脂及胰岛素抵抗等相关指标的关系,Logistic逐步回归分析2型糖尿病并发脑梗死的影响因素。结果A组血清网膜素1、脂联素水平较其他两组低(P均0.05),B组较C组低(P均0.05)。血清网膜素1、脂联素与腰臀比、体质量指数、舒张压、空腹血糖、胰岛素抵抗指数、糖化血红蛋白、甘油三酯呈负相关(P均0.05),与低密度脂蛋白胆固醇呈正相关(P均0.05),血清网膜素1与脂联素呈正相关(P均0.05)。血清网膜素1、脂联素是2型糖尿病发病的影响因素(P均0.05),也是2型糖尿病并发脑梗死的影响因素(P均0.05)。结论老年2型糖尿病合并脑梗死患者血清网膜素1、脂联素水平降低,二者共同参与该病的发生发展。
[Abstract]:Objective to observe the changes of serum omentin-1 and adiponectin levels in elderly patients with type 2 diabetes mellitus complicated with cerebral infarction. Methods 50 patients with type 2 diabetes mellitus complicated with cerebral infarction, 50 patients with type 2 diabetes mellitus with cerebral infarction, 50 patients with type 2 diabetes mellitus with cerebral infarction, 50 patients with type 2 diabetes mellitus with cerebral infarction, 50 patients with type 2 diabetes mellitus with cerebral infarction, 50 patients with type 2 diabetes mellitus with cerebral infarction, 50 patients with type 2 diabetes mellitus with cerebral infarction, 50 patients with physical examination. The serum levels of omentin 1 and adiponectin were measured by enzyme linked immunosorbent assay (Elisa), and the levels of serum omentin 1, adiponectin and blood glucose, blood pressure were analyzed by linear correlation analysis. Logistic stepwise regression analysis showed that serum omentin 1 and adiponectin levels in group A were lower than those in other two groups (P < 0.05 or P < 0.05). Serum omentin 1, adiponectin to waist-hip ratio, Body mass index, diastolic blood pressure, fasting blood glucose, insulin resistance index, glycosylated hemoglobin, There was a negative correlation between triglyceride and low density lipoprotein cholesterol (LDL-C) (P < 0.05), and a positive correlation between serum omentin-1 and adiponectin (P = 0.05). Conclusion Serum omentin 1 and adiponectin level in elderly patients with type 2 diabetes mellitus complicated with cerebral infarction were lower than those in elderly patients with type 2 diabetes mellitus complicated with cerebral infarction. Both participate in the occurrence and development of the disease.
【作者单位】：桂林市人民医院;
【基金】：桂林市科学研究与技术开发计划项目(2016012704-5)
【分类号】：R587.1;R743.3

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