血清IL-27对类风湿性关节炎早期诊断特异性及敏感性作用分析

发布时间：2018-02-16 10:38

本文关键词： 白细胞介素- 鉴别诊断类风湿性关节炎　出处：《中国地方病防治杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨血清中白细胞介素-27(IL-27)早期鉴别诊断类风湿性关节炎的临床价值。方法选取2013年1月至2015年12月在本院接受诊治的96例类风湿性关节炎患者作为病例组,选取同期健康体检对象60例作为对照组,分别测定血清IL-27水平,分析IL-27与其他血清因子的关系,并采用ROC曲线分析IL-27鉴别诊断类风湿性关节炎的诊断学效能。结果病例组患者的ESR、hs-CRP、RF、IL-25、IL-27水平均显著的高于对照组,差异均具有统计学意义(P0.05);类风湿性关节炎患者的血清IL-27水平与血清ESR、hs-CRP、RF、IL-25均呈显著的正相关性关系(P0.05);绘制ROC曲线,选取最大曲线下面积AUC值为0.841时,对应的IL-27的临界值为98.50 pg/ml,对应的灵敏度为78.90%、特异度为72.54%。结论 IL-27早期鉴别诊断类风湿性关节炎具有一定的临床价值,并且与患者的ESR、hsCRP、RF等因子具有一定的关系。
[Abstract]:Objective to investigate the clinical value of early differential diagnosis of rheumatoid arthritis (RA) by interleukin-27 (IL-27) in serum. Methods 96 patients with rheumatoid arthritis who were treated in our hospital from January 2013 to December 2015 were selected as the case group. In the same period, 60 healthy subjects were selected as control group, the serum IL-27 level was measured, and the relationship between IL-27 and other serum factors was analyzed. The diagnostic efficacy of IL-27 in differential diagnosis of rheumatoid arthritis was analyzed by ROC curve. Results the levels of IL-25 IL-27 in patients with rheumatoid arthritis were significantly higher than those in the control group. There was a significant positive correlation between the serum IL-27 level and serum ESRHs-CRPnRFIL-25 in patients with rheumatoid arthritis. The ROC curve was drawn and the area AUC value under the maximum curve was 0.841. The critical value of IL-27 is 98.50 PG / ml, the sensitivity is 78.90, and the specificity is 72.54. Conclusion the early differential diagnosis of rheumatoid arthritis with IL-27 has some clinical value, and has a certain relationship with the factors such as IL-27 hsCRPRF.
【作者单位】：西南医科大学附属医院;
【基金】：国家自然科学基金资助项目,编号:31300946
【分类号】：R593.22

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