龈沟血糖化血红蛋白筛查糖尿病的应用研究

发布时间：2018-02-21 17:40

本文关键词： 牙周炎糖尿病龈沟血糖化血红蛋白　出处：《口腔医学研究》2017年08期 　论文类型：期刊论文

【摘要】：目的:评估在牙周探诊中获得的龈沟血(gingival crevicular blood,GCB)的糖化血红蛋白(HbAlc)是否可以代替手指末梢血(finger stick capillary blood,FSB)来筛查糖尿病(diabetes mellitus,DM)的可靠性,为DM筛查提供新渠道。方法:选取中重度慢性牙周炎患者,血糖仪检测GCB和FSB的血糖,Bio-rad D10全自动糖化血红蛋白分析仪检测GCB和FSB的HbAlc,Pearson相关系数分析GCB和FSB血糖以及HbAlc的相关性,受试者工作特征(receiver operating characteristic,ROC)曲线确定GCB HbAlc对DM的最佳诊断界值。结果:本研究收集了60例中重度慢性牙周炎患者,根据有无DM史、FSB血糖以及HbAlc的结果,发现18例有DM、42例无DM的牙周炎患者,两组GCB和FSB血糖的相关性分别为r=0.993和r=0.926;HbAlc的相关性分别为r=0.977和r=0.829;ROC曲线确定GCB HbAlc对DM的最佳诊断界值为HbAlc=5.7%,灵敏度为100%,特异度为95.2%。结论:与FSB HbA1c相比,牙周探诊获得的GCB进行HbA1c检测同样准确,最佳诊断界值为GCB HbAlc=5.7%,可能用于筛查DM患者。
[Abstract]:Objective: to evaluate the reliability of the glycosylated hemoglobin (HbAlc) of gingival crevicular blood (GCBs) obtained during periodontal diagnosis, instead of finger stick capillary blood capillary (FSBs), for the screening of diabetic diabetes mellitus (DM). Methods: the blood glucose of GCB and FSB was detected by blood glucose analyzer Bio-rad D10 automatic glycosylated hemoglobin analyzer was used to detect the correlation between GCB and FSB blood glucose and HbAlc in GCB and FSB by HbAlc Pearson correlation coefficient. The receiver operating characteristic curve was used to determine the best diagnostic value of GCB HbAlc for DM. Results: in this study, 60 patients with moderate or severe chronic periodontitis were collected according to the results of FSB blood glucose and HbAlc. Eighteen patients with DMN and 42 patients with periodontitis without DM were found. The correlation between GCB and FSB blood glucose in the two groups was r = 0.993 and r ~ (0.926) HbAlc, respectively. The correlation was r ~ (0.977) and ~ (0.829) ~ ROC respectively. The best diagnostic threshold of GCB HbAlc for DM was determined to be HbAlc ~ (5. 7), sensitivity was 100, specificity was 95. 2. Conclusion: compared with FSB HbA1c, the best diagnostic value of GCB HbAlc for DM is 100, and the specificity is 95. 2. Conclusion: compared with FSB HbA1c, The GCB obtained from periodontal exploration is also accurate for HbA1c detection. The best diagnostic threshold is GCB HbAlcC5. 7, which may be used to screen DM patients.
【作者单位】：南京大学医学院附属口腔医院南京市口腔医院牙周科;江苏省苏北人民医院医学检验科;南京医科大学附属儿童医院口腔科;
【基金】：国家自然科学基金(编号:51472115) 南京市医学科技发展项目(编号:YKK15165)
【分类号】：R587.1;R781.42

【相似文献】