不同抗菌治疗对老年糖尿病合并肺部感染患者血清学指标及疗效的影响研究

发布时间：2018-02-24 09:34

本文关键词： 抗菌治疗老年糖尿病肺部感染血清学指标　出处：《中华医院感染学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的探讨不同抗菌治疗方案对老年糖尿病合并肺部感染患者血清学指标和疗效的影响。方法选取医院2014年4月-2016年2月应用头孢他啶联合氨溴索治疗的58例老年糖尿病合并肺部感染患者为观察组,头孢噻肟钠联合氨溴索治疗的60例患者作为对照组,比较两组用药前后血清学指标的变化,同时在用药10d后对疗效和药物不良反应。结果治疗后两组血清内皮素(ET)、C-反应蛋白(CRP)、白细胞计数(WBC),降钙素基因相关肽(CGRP)与治疗前差异有统计学意义(P0.05),观察组CD_4~+/CD_8~+明显改善,对照组CD_4~+/CD_8~+无明显改善,治疗后观察组ET、CRP、WBC、CGRP、CD_4~+/CD_8~+分别为(41.63±5.17)ng/L、(51.39±8.67)mg/L、(8.37±4.25)×10~9/L、(67.53±5.43)ng/L、(1.56±0.23)表达水平显著优于对照组(58.37±6.03)ng/L、(87.69±8.75)mg/L、(11.68±4.37)×10~9/L、(50.34±4.56)ng/L、(1.04±0.15)(P0.05);观察组总有效率为82.76%显著高于对照组66.67%(P0.05);观察组并发症发生率为8.62%明显低于对照组16.67%(P0.05)。结论头孢他啶联合氨溴索作为广谱杀菌方案,不仅能显著抑制血清炎性因子表达,能有益调节免疫功能。
[Abstract]:Objective to investigate the effect of different antimicrobial regimens on serological indexes and efficacy in elderly patients with diabetes mellitus complicated with pulmonary infection. Methods 58 elderly patients treated with ceftazidime combined with ambroxol from April 2014 to February 2016 were selected. Patients with diabetes complicated with pulmonary infection were treated as observation group. 60 patients treated with cefotaxime sodium combined with ambroxol were used as control group to compare the changes of serological indexes before and after treatment. Results after 10 days of treatment, there were significant differences between the two groups in serum endothelin (et), C-reactive protein (CRP), white blood cell count (WBCU), calcitonin gene-related peptide (CGRP) and pre-treatment (P 0.05). In the control group, CD4 ~ / CD8 had no significant improvement, After treatment, the expression levels of ETCRP- WBCC- CGRPnP + CD4 ~ /-CD8 in the observation group were 41.63 卤5.17 ng / L, 51.39 卤8.67 mg / L, 8.37 卤4.25) 脳 10 ~ 9 mg / L respectively, 67.53 卤5.43 ng / L ~ (1.56 卤0.23) and 58.37 卤6.03 ng / L ~ (-1. 56 卤0.23) respectively; the incidence of complications in the observation group was significantly higher than that in the control group (58.37 卤6.03 ng / L = 11.68 卤4.37) 脳 10 ~ (9) Lng / L = 50.34 卤4.56ng / L = 1.04 卤0.15ng / L / L ~ (1.04) 卤0.15ng / L respectively; the overall effective rate in the observation group was significantly higher than that in the control group (66.37 卤6.03ng / L) and the incidence of complications in the observation group was significantly lower than that in the control group. Conclusion the incidence of complications in the observation group is significantly lower than that in the control group. Conclusion the incidence of complications in the observation group is significantly lower than that in the control group. Conclusion the incidence of complications in the observation group is significantly higher than that in the control group. Conclusion the incidence of complications in the observation group is significantly lower than that in the control group. As a broad-spectrum bactericidal scheme, Not only can significantly inhibit the expression of serum inflammatory factors, can be beneficial to regulate the immune function.
【作者单位】：遵义市第一人民医院内分泌科;
【分类号】：R563.1;R587.2

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