Roux-en-Y吻合重建对胃癌合并糖尿病患者血胰岛功能的影响

发布时间：2018-02-25 08:42

本文关键词： 胃癌糖尿病血糖胰岛功能　出处：《中国糖尿病杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的探讨Roux-en-Y吻合重建对胃癌合并T2DM患者血糖水平、胰岛功能及并发症的影响。方法根据手术方式将120例Ⅰ~Ⅱ期胃癌合并T2DM患者随机分为观察组62例及对照组58例,对照组行胃食管吻合术,观察组行Roux-en-Y吻合重建术,比较两组治疗前后血糖及胰岛素的变化。结果术后6个月,观察组BMI[(23.36±2.44)vs(25.33±2.92)kg/m2]、FPG[(5.58±2.02)vs(8.96±1.75)mmol/L]、2hPG[(10.36±3.22)vs(13.82±2.77)mmol/L]、HbA1c[(4.28±1.36)%vs(9.22±1.25)%]、HOMA-IR[(2.12±0.85)vs(4.02±1.22)mIU/L]、HOMA-β[(3.89±0.82)vs(4.58±0.79)mmol/L]均低于对照组(P0.05)。观察组术后6个月FIns[(14.28±1.33)vs(10.78±2.36)mIU/L]、FC-P[(3.98±1.02)vs(1.39±0.45)μg/L]、2hIns[(38.12±3.98)vs(33.28±4.15)mIU/L]、2hC-P[(9.86±2.12)vs(5.18±1.52)μg/L]较术前升高(P0.05)。观察组近期并发症发生率和远期并发症发生率均低于对照组[3.22%vs 17.20%;4.84%vs 18.96%,P0.05]。结论 Roux-en-Y吻合术能有效改善胃癌合并T2DM患者胰岛β细胞功能,降低血糖水平,术后并发症发生率低,安全有效。
[Abstract]:The results showed that the incidence of postoperative complications and the incidence of long - term complications in patients with gastric cancer complicated with T2DM were significantly lower than those in the control group ( P < 0.05 ) . The results showed that the incidence of postoperative complications and the incidence of long - term complications were significantly lower in the observation group than in the control group ( P < 0.05 ) .

【作者单位】：兰州大学第一医院普外一科;
【基金】：甘肃省中医药科技技术研究课题(GZK-2011-62)
【分类号】：R735.2;R587.1

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