曲美他嗪早期干预对糖尿病大鼠左室功能及超微结构的影响

发布时间：2018-02-26 17:07

本文关键词： 曲美他嗪糖尿病速度向量成像　出处：《中国超声医学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的速度向量成像(VVI)评价曲美他嗪早期干预对糖尿病大鼠左室功能的影响。方法SD大鼠随机分糖尿病组(DM)、曲美他嗪组(TMZ)和对照组(NC)。链脲佐菌素诱导DM模型,TMZ组曲美他嗪10mg/(kg·d)灌胃,NC组和DM组生理盐水灌胃,治疗8周后行VVI检查,并取心肌组织透射电镜检测。结果除收缩期径向峰值速度(Vs)外,TMZ组舒张期径向峰值速度(Vd)、径向峰值应变(Sr)、收缩和舒张期径向峰值应变率(收缩期SRr、舒张期SRr)、切向峰值应变(Sc)、收缩和舒张期切向峰值应变率(收缩期SRc、舒张期SRc)均较DM组增高(P均0.05)。TMZ组心肌纤维及线粒体结构较DM组改善。结论曲美他嗪早期干预能改善心肌超微结构,增强糖尿病大鼠左室收缩和舒张功能。
[Abstract]:Objective to evaluate the effect of early intervention of trimetazidine on left ventricular function in diabetic rats by velocity vector imaging (VVI). Methods SD rats were randomly divided into diabetic group (DMN), trimetazidine group (TMZ) and control group (control group). Streptozotocin induced DM model and TMZ suture were randomly divided into two groups: diabetes mellitus group (DM group), trimetazidine group (TMZ group) and control group (control group). Metazin 10 mg / kg 路d) was given intragastric with normal saline in NC group and DM group. After 8 weeks of treatment, VVI was performed. Results with the exception of systolic radial peak velocity (Vs), the radial peak velocity of diastolic phase (VdN), the radial peak strain (RSR), the radial peak strain (RSR), the peak strain rate (SRR) of contraction and diastole (SRR) in TMZ group, and the radial peak strain rate in diastolic phase (SRR, SRR, tangential direction) were measured by electron microscopy. The peak strain, systolic and diastolic tangential peak strain rate (SRC) were higher than DM group (P 0.05). TMZ group was better than DM group in myocardial fiber and mitochondria structure. Conclusion early intervention with trimetazidine can improve myocardial ultrastructure. To enhance left ventricular systolic and diastolic function in diabetic rats.
【作者单位】：西安市儿童医院超声科;第四军医大学西京医院超声科;
【基金】：国家自然科学基金面上项目(No.81271580)
【分类号】：R587.2;R542.2

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