牙周非手术治疗对肥胖大鼠血清炎症指标及代谢水平的影响

发布时间：2018-02-27 21:09

本文关键词： 牙周非手术治疗肥胖炎症因子代谢水平　出处：《南方医科大学学报》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨牙周非手术治疗对肥胖大鼠血清炎症因子及代谢水平的影响。方法选取16只已成功建立肥胖复合牙周炎模型的大鼠,随机分为治疗组及未治疗组(对照组),治疗组大鼠接受牙周非手术治疗,对照组未做任何处理,所有大鼠于牙周治疗后2周处死。牙周治疗前及治疗后2周两组大鼠均行口服糖耐量试验,眼眶静脉取血、检测空腹血糖及空腹胰岛素,运用酶联免疫吸附法检测血清C-反应蛋白(CRP)。结果牙周治疗后2周,治疗组的空腹血糖(t=2.445,P=0.034)及β细胞功能指数显著低于对照组(t=-2.543,P=0.027);经牙周治疗后,治疗组CRP水平显著降低,并低于对照组(t=2.388,P=0.028);口服糖耐量试验中,曲线下面积显著下降,并低于对照组(t=12.053,P=0.000)。结论牙周非手术治疗可以下调肥胖复合牙周炎大鼠的CRP水平,改善肥胖大鼠的糖代谢状况。
[Abstract]:Objective to investigate the effect of non-surgical periodontal therapy on serum inflammatory factors and metabolic level in obese rats. Methods 16 has successfully established periodontitis model compound in obese rats, were randomly divided into treatment group and non treatment group (control group), treatment group rats received non-surgical periodontal treatment, the control group did not any treatment, all rats were killed 2 weeks after periodontal treatment. Periodontal treatment before and 2 weeks after treatment in two groups of rats underwent oral glucose tolerance test, orbital blood test, fasting blood glucose and fasting insulin, using enzyme-linked immunosorbent assay of serum C- reaction protein (CRP) results periodontal treatment after 2 weeks of treatment group, fasting blood glucose (t=2.445, P=0.034) and beta cell function index was significantly lower than the control group (t=-2.543, P=0.027); after periodontal treatment, the treatment group CRP was significantly lower, and lower than that of the control group (t=2.388, P= 0.028); oral glucose tolerance test, The area under the curve decreased significantly, which was lower than that in the control group (t=12.053, P=0.000). Conclusion nonoperative periodontal treatment can reduce the CRP level in obese rats with periodontitis and improve the glucose metabolism in obese rats.

【作者单位】：南方医科大学口腔医院//广东省口腔医院牙体牙髓科;中国科学院大学存济医学院;
【基金】：国家自然科学基金(81300890)~~
【分类号】：R589.2;R781.4

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