靶向代谢组学技术在营养性疾病研究中的应用

发布时间：2018-03-02 07:36

本文关键词： 靶向代谢组学营养性疾病脂肪代谢糖代谢氨基酸代谢　出处：《食品工业科技》2017年18期 　论文类型：期刊论文

【摘要】：营养性疾病发生是营养素失衡的体现,是体内一类或几类物质代谢异常的结果,尤其是与饮食中脂肪、糖类、蛋白质等密切相关的脂质代谢、糖代谢、氨基酸代谢等。因此,以营养性疾病的代谢物着手,运用靶向代谢组学技术找到丰度改变有统计学意义的内源性代谢物从而探明其代谢异常的机制,是寻找具有针对性的治疗手段的有效方法。本文就肥胖、糖尿病、心血管疾病等营养性疾病的代谢特征以及靶向代谢组学技术在营养性疾病动物模型和营养干预等研究中的应用进展进行综述,以期为寻找预防营养性疾病的发生的有效途径提供新思路和理论依据。
[Abstract]:The occurrence of nutritional diseases is the manifestation of nutrient imbalance and the result of abnormal metabolism of one or more kinds of substances in the body, especially lipid metabolism, sugar metabolism, amino acid metabolism and so on, which are closely related to fat, sugar and protein in diet. Starting with the metabolites of nutritious diseases and using targeted metabonomics, we can find out the mechanism of abnormal metabolism of endogenous metabolites with significant changes in abundance. Is an effective way to find targeted treatment. The metabolic characteristics of nutritional diseases such as cardiovascular diseases and the application of targeted metabolic techniques in animal models of nutritional diseases and nutritional intervention are reviewed. In order to find an effective way to prevent the occurrence of nutritional diseases to provide new ideas and theoretical basis.
【作者单位】：北京食品营养与人类健康高精尖创新中心食品添加剂与配料北京高校工程研究中心北京工商大学;
【基金】：国家自然科学基金(31501480,31571940) 北京市留学人才科技活动项目优秀类项目
【分类号】：R591

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