3TMRI3D-WATS及增强序列结合抗CCP抗体检查对早期RA手关节病变的诊断价值

发布时间：2018-03-02 08:40

本文关键词： 关节炎类风湿 3D-WATS及增强磁共振成像抗环瓜氨酸肽抗体　出处：《青海大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:研究磁共振(MRI)3D-WATS技术成像及增强序列结合血清抗环瓜氨酸肽(CCP)抗体的水平对发现手关节早期类风湿关节炎(RA)的意义。方法:收集多关节肿痛患者34例,男性10例,平均年龄56.8岁;女性24例,平均年龄46.8岁,总平均年龄49.0±14.1岁。行双腕关节及掌指关节MRI扫描,采用自旋回波(SE)、T2W-STIR、3D-WATS序列、增强扫描序列。同时测定患者血清抗CCP抗体的水平。实验室检查与影像学检查进行综合评定,诊断早期类风湿关节炎。结果:共采集病例数34例。其中初诊及随诊中病情进展符合2010年美国风湿病学会(ACR)RA诊断标准确诊的RA患者28例,早期RA患者20例,确诊患者8例,6例患者为其他炎性病变。早期RA患者中抗CCP抗体阳性者14例,阳性率为70%。18例患者MRI显示滑膜炎,16例有骨髓水肿,18例有骨侵蚀。早期RA组20例患者中,14例可显示血管翳形成,出现率达到70%。结论:MRI 3D-WATS及增强序列扫描结合抗CCP抗体检测有助于早期RA的诊断。
[Abstract]:Objective: to study the significance of MRI- 3D-WATS imaging and enhanced sequence combined with serum anti-cyclic citrullin-peptide (CCPP) antibody in the detection of early rheumatoid arthritis (RA) of the hand joint. Methods: 34 patients with multiarticular swelling and pain, 10 males, were collected. The mean age was 56.8 years, the average age was 46.8 years old in 24 females, the total average age was 49.0 卤14.1 years old. MRI scanning was performed on the wrist and metacarpophalangeal joints, and the T2W-STIR3D-WATS sequence was used to scan the wrist joints and metacarpophalangeal joints. Enhanced scanning sequence. Serum levels of anti CCP antibodies were also measured. Laboratory and imaging examinations were used for comprehensive evaluation. Results: 34 cases of rheumatoid arthritis were diagnosed. Among them, 28 cases of RA were diagnosed according to the diagnostic criteria of ACR-RA in 2010 and 20 cases of early RA. Other inflammatory lesions were found in 8 patients and 6 patients. Among the early RA patients, 14 were positive for anti CCP antibody. The positive rate of MRI was 70. 18 patients with synovitis, 16 with bone marrow edema and 18 with bone erosion. 14 of 20 patients in early RA group showed pannus formation. Conclusion MRI 3D-WATS and enhanced sequence scan combined with anti CCP antibody detection are helpful for early diagnosis of RA.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R445.2;R593.22

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