应用糖皮质激素的糖尿病患者胰岛素治疗方案探讨

发布时间：2018-03-03 06:27

本文选题：糖皮质激素　切入点：糖尿病　出处：《中国糖尿病杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨应用糖皮质激素糖尿病患者的临床特点及胰岛素治疗。方法选取应用中效糖皮质激素并于清晨1次给药的糖尿病患者60例,随机分为预混人胰岛素(30R)治疗组(30R组)、3次门冬胰岛素+1次重组甘精胰岛素治疗组(3+1IN组)两组。30R组予精蛋白生物合成人胰岛素30R早、中餐前皮下注射治疗;3+1IN组予门冬胰岛素3餐前加重组甘精胰岛素睡前皮下注射治疗。结果各组治疗后各时刻血糖均较治疗前好转(P0.01);30R组3餐后2 h、睡前、02:00血糖与3+1IN组比较,差异无统计学意义(P0.05);与3+1IN组比较,30R组FPG升高[(4.8±0.6)vs(6.0±0.9)mmol/L,P0.05];中、晚餐前血糖降低[(8.7±1.3)vs(7.1±1.0)mmol/L,(10.2±1.7)vs(7.4±1.2)mmol/L,P0.05]。结论预混人胰岛素30R早、中餐前皮下注射治疗应用糖皮质激素清晨1次给药的糖尿病患者有较好的临床疗效,且方案简单,值得推广。
[Abstract]:Objective to investigate the clinical characteristics and insulin therapy of patients with glucocorticoid diabetes mellitus. The rats were randomly divided into two groups: the premixed human insulin 30R) group (30 R group) and the control group (30 R group) treated with recombinant insulin glargine once 3 times (3 1IN group). Group 30R was treated with protamine biosynthetic human insulin 30R early. The subcutaneous injection group was treated with subcutaneous injection of Aspartic insulin before meal and recombination glargine insulin before bedtime. Results the blood glucose at every time after treatment in each group was higher than that in group P0.01 + 30R at 2 hours after meal, and the blood glucose of 0 2: 00 before bedtime was compared with that of group 3 in 1 IN. Compared with 31IN group, the FPG of 30R group increased [4.8 卤0.6 vs 6.0 卤0.9 mmol / L P 0.05], and the blood glucose decreased before dinner [8.7 卤1.3 vs 7.1 卤1.0 mmolL / L]. Conclusion Premixed human insulin 30R is early, and it is lower than that of 31IN group [8.7 卤1.3 vs 7.1 卤1.0 渭 mol / L, P < 0.05, P < 0.05]. Chinese preprandial subcutaneous injection of glucocorticoid in the treatment of diabetes patients once in the morning has a better clinical efficacy, and the program is simple, worthy of promotion.
【作者单位】：滨州市人民医院内分泌科;
【分类号】：R587.1

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