2型糖尿病患者空腹C肽水平与冠状动脉病变的相关性研究

发布时间：2018-03-04 06:29

本文选题：型糖尿病　切入点：空腹C肽　出处：《临床心血管病杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨2型糖尿病(DM)患者空腹C肽(FCP)水平对发生冠状动脉(冠脉)疾病(CAD)的影响,为明确FCP与2型DM心血管病变之间的相关性提供理论依据。方法:采用横断面调查方法收集2015-03-2017-03于我院内分泌科住院的单纯2型DM患者及2型DM合并CAD患者615例,记录入选患者一般临床资料及各项实验室检查指标,按照是否合并CAD及病变程度分为单纯糖尿病组(DM组,292例)和合并冠脉轻度病变组(DM+CAD1组,86例)、合并冠脉中度病变组(DM+CAD2组,150例)、合并冠脉重度病变组(DM+CAD3组,87例)。比较各组的FCP水平的差异,多元线性回归分析影响FCP的因素,并利用多分类logistic逐步回归分析探讨不同冠脉病变程度与FCP的关系。结果:2型DM合并冠脉病变患者体内FCP高于单纯DM患者[(0.57±0.32):(0.74±0.56),P0.05],且随着病变程度的增加,FCP升高显著。双变量相关分析显示FCP与糖化血红蛋白呈负相关(r=-0.256,P=0.000),与体质指数、血尿酸、超敏C反应蛋白、颈动脉内中膜厚度呈正相关(r=0.190,0.219,0.171,0.180,P均为0.000)。多分类logistic回归分析显示,FCP、年龄是DM合并冠脉病变的危险因素,心率是保护因素。结论:FCP水平可以在一定程度上反映应DM合并CAD的发生风险,FCP越高,DM合并CAD的可能越大。
[Abstract]:Objective: to investigate the effect of fasting C-peptide FCPP on coronary artery disease (CAD) in patients with type 2 diabetes mellitus (DM). Methods: a cross-sectional survey was conducted in 615 patients with type 2 DM and type 2 DM complicated with CAD who were admitted to the Endocrinology Department in our hospital in 2015-03-2017-03. To record the general clinical data and laboratory examination indexes of the selected patients, According to whether or not to combine CAD and the degree of lesion, we divided them into two groups: diabetes mellitus group (n = 292), mild coronary artery disease group (n = 86), moderate coronary artery disease group (n = 150) CAD2 group (n = 150) and severe coronary artery disease group (n = 87). To compare the difference of FCP level in each group, Factors affecting FCP by multivariate linear regression analysis, Using multi-classification logistic stepwise regression analysis, the relationship between the degree of coronary artery disease and FCP was studied. Results the FCP in patients with type 2 DM complicated with coronary artery disease was higher than that in patients with simple DM [0.57 卤0.32: 0.74 卤0.56, P0.05], and increased significantly with the increase of pathological degree. Variable correlation analysis showed that there was a negative correlation between FCP and glycosylated hemoglobin (FCP) and body mass index (BMI). Serum uric acid, hypersensitive C-reactive protein, carotid intima-media thickness were positively correlated with 0.219U 0.171 ~ 0.180.P = 0.0000.0.000 logistic regression analysis showed that age was a risk factor for DM complicated with coronary artery disease. Conclusion the level of FCP can reflect the risk of DM combined with CAD to some extent. The higher the risk of FCP is, the higher the risk of DM and CAD is.
【作者单位】：广州军区武汉总医院内分泌科;南方医科大学;
【基金】：湖北省科技计划项目(No:2012FFB06807)
【分类号】：R587.2

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