糖尿病足患者多药耐药菌感染的危险因素logistic回归分析

发布时间：2018-03-05 12:57

本文选题：糖尿病足　切入点：多药耐药菌　出处：《中华医院感染学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨糖尿病足患者多药耐药菌感染的危险因素,为制定临床防治措施提供理论依据。方法回顾性分析医院2014年1月-2016年6月收治192例糖尿病足患者的临床资料,分析多药耐药菌的分布情况,对比患者的各项临床资料,并通过多因素logistic回归分析,探讨糖尿病足患者多药耐药菌感染的危险因素。结果 61例患者发生多药耐药菌感染,感染率为31.77%;93株多药耐药菌中,检出金黄色葡萄球菌41株(44.09%),检出铜绿假单胞菌20株(21.51%);使用抗菌药物、第三代头孢菌素类抗菌药物、有神经缺血性伤口、同一溃疡面住院2次、发生骨髓炎的多药耐药感染率均显著高于无使用抗菌药物、无使用第三代头孢菌素类抗菌药物、无神经缺血性伤口、同一溃疡面住院≤2次、未发生骨髓炎的多药耐药感染率,差异有统计学意义(P0.05);多因素logistic回归分析显示,使用抗菌药物、有神经缺血性伤口、同一溃疡面住院2次以及骨髓炎是糖尿病足患者多药耐药菌感染的危险因素(P0.05)。结论糖尿病足发生多药耐药菌感染的风险较高,临床应针对发生多药耐药菌感染的危险因素,制定有效的防治措施,以提高疾病的诊疗效果,改善患者预后。
[Abstract]:Objective to explore the risk factors of diabetic foot in patients with multi drug resistant bacteria infection, and provide a theoretical basis for clinical treatment. Methods Retrospective analysis of hospital in January 2014 -2016 in June admitted to the clinical data of 192 patients with diabetic foot, the distribution of multidrug-resistant bacteria, compared to the clinical data of patients, and through multi factor Logistic regression analysis of risk factors of diabetic foot in patients with multi drug resistant bacteria infection. Results among 61 patients with multi drug resistant bacteria infection, the infection rate was 31.77%; 93 strains of multi drug resistant bacteria, detection of Staphylococcus aureus, 41 strains (44.09%) were detected in 20 strains of Pseudomonas aeruginosa (21.51%) use; antibiotics, third generation cephalosporins, nerve ischemic wound, the same ulcer hospital 2 times, multidrug resistance and osteomyelitis infection rate was significantly higher than that of no use of antimicrobial drugs, without the use of the third generation Cephalosporins, no nerve ischemic wound, the same ulcer hospitalization less than or equal to 2 times of multidrug resistance occurred osteomyelitis infection rate, the difference was statistically significant (P0.05); logistic regression analysis showed that the use of antibacterial drugs, nerve ischemic wound, with an ulcer hospital 2 times and osteomyelitis is dangerous the factors of diabetic foot in patients with multi drug resistant bacteria infection (P0.05). The foot occurs at higher risk of multi drug resistant bacterial infection conclusion diabetes, clinical should be aimed at the risk of multi drug resistant bacteria infection factors, develop prevention measures, to improve disease diagnosis and treatment, improve the prognosis of patients.

【作者单位】：郑州人民医院内分泌科;
【基金】：河南省基础与前沿技术研究项目(102300410038)
【分类号】：R587.2

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