地方性氟中毒与老年性白内障相关性分析

发布时间：2018-03-06 13:48

本文选题：地方性氟中毒　切入点：白内障　出处：《中国地方病防治杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的研究探讨地方性氟中毒与老年性白内障患者发病间的相关性,以期为老年性白内障患者的防治提供参考。方法对本市2015年1月至2015年12月期间同一乡镇的地方性氟中毒病区和非病区人群进行大样本量的流行病学调查,观察比较在这一年内不同地区人群新患老年性白内障患者的发病率,同时对地方性氟中毒病区和非病区老年性白内障患者的晶体氟含量进行检测比较。紧接着在2016年1月至2016年12月对地方性氟中毒病区更换饮用水前后新增老年性白内障患者的发病率进行比较分析。结果 (1)对这一年中地方性氟中毒病区2871例患者进行调查,结果发现新增老年性白内障患者79例,发病率为2.75%,对3107例非地方性氟中毒病区人群进行调查,结果发现新增患有老年性白内障患者25例,患病率为0.81%,两组人群间新增白内障患者发病率差异显著(P0.05),提示氟中毒患者更容易患上白内障。(2)地方性氟中毒病区79例老年性白内障患者经检查晶体氟含量为(1.28±0.23)mg/l,非病区25例老年性白内障患者晶体氟含量为(0.31±0.06)mg/l,提示氟中毒老年性白内障患者晶体氟含量显著高于非氟中毒老年性白内障患者(P0.05);(3)氟中毒地区更换低氟饮用水后,老年性白内障患者的发病率显著降低(P0.05),提示地方性氟中毒患者老年性白内障的发病与氟含量的高低密切相关。结论地方性氟中毒与老年性白内障患者间存在明显的相关性,氟中毒人群中出现老年性白内障的发病率较高,且晶体氟含量高于非病区老年行白内障患者,降低病区饮用水中的氟含量可减少老年性白内障患者的发病率,可为老年性白内障的防治提供参考。
[Abstract]:Objective to study the relationship between endemic fluorosis and senile cataract. Methods from January 2015 to December 2015, the population of endemic fluorosis and non-endemic fluorosis in the same town were investigated by epidemiological survey. To observe and compare the incidence of new senile cataract patients in different areas during the year. At the same time, the content of fluoride in senile cataract patients in endemic fluorosis area was compared with that in non-endemic area. Then, from January 2016 to December 2016, new senile patients were added before and after the replacement of drinking water in endemic fluorosis area. The incidence of cataract was compared and analyzed. Results: a total of 2871 cases of endemic fluorosis were investigated in this year. The results showed that there were 79 new senile cataract patients and the incidence rate was 2.75.The results showed that there were 25 new senile cataract patients in 3107 non-endemic fluorosis areas. The prevalence rate was 0.81.The difference of incidence of new cataract between the two groups was significant (P 0.05), suggesting that fluorosis patients are more likely to suffer from cataract. 2) 79 cases of senile cataract patients in endemic fluorosis area were examined to have a fluoride content of 1.28 卤0.23 mg / L, non-fluorosis. The content of fluoride in 25 senile cataract patients was 0.31 卤0.06 mg / L, which suggested that the fluoride content in senile cataract patients with fluorosis was significantly higher than that in non-fluorosis senile cataract patients (P 0.05). The incidence of senile cataract decreased significantly, suggesting that the incidence of senile cataract was closely related to the level of fluoride in endemic fluorosis patients. Conclusion there is a significant correlation between endemic fluorosis and senile cataract. The incidence of senile cataract in fluorosis population was higher, and the fluoride content of lens was higher than that of senile cataract patients in non-endemic area. Reducing the fluoride content in drinking water of endemic area could reduce the incidence of senile cataract. It can provide reference for the prevention and treatment of senile cataract.
【作者单位】：川北医学院附属医院眼科;浙江温医雷赛医用激光科技有限公司;
【基金】：2013年度省国际科技合作专项计划(2013C14010)
【分类号】：R599.1;R776.1

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