系统性红斑狼疮与海拔及季节因素关系的研究

发布时间：2018-03-07 05:38

本文选题：系统性红斑狼疮　切入点：海拔　出处：《昆明医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的分析云南省不同海拔地区和不同季节系统性红斑狼疮(systemic lupus erythematosus, SLE)患者的临床表现,疾病活动与海拔之间的关系。方法回顾性分析2002年1月至2012年12月1029例入院SLE患者的住院病历,统计分析不同海拔人群及不同季节患者的临床和实验室结果的分布特征,分析各器官疾病活动度与海拔、季节之间的关系。结果 1.住院病人入院前居住地海拔从553米到3500米不等。高海拔地区患者的发病年龄分别较中等海拔和低海拔地区小；随着海拔升高,SLE患者住院年龄越小。2.高海拔地区的SLE患者起病到首次就诊时间短于中海拔地区。3.高海拔地区Anti-Sm抗体阳性的患者比率要高于中海拔地区；高海拔地区的贫血患者比率较中海拔地区高；低海拔地区血小板减少的患者比率较中、高海拔地区低；高海拔地区肌酐升高(133μmol/l)的患者比率要比中海拔地区高。4.SLE患者SLEDAI评分与海拔之间没有显著性差异。5.在SLE非活动性患者中,免疫系统、肾脏各活动等级患者比率的变化与海拔变化相关,随着海拔的升高而成增加趋势。6.在SLE活动性患者中,精神神经损害的不同活动等级患者比率的变化与海拔变化相关,随着海拔的升高而成增加趋势,而关节不同活动等级的患者比率随着海拔的升高而成下降趋势。7.春夏秋冬四季发病的SLE住院病人中,患者起病年龄和住院年龄在冬季均较其他三季大。8.在SLE非活动性患者中,免疫系统活动等级患者比率春季损害最高,其次为秋季和夏季患者,冬季组的损害最轻。9.在SLE活动性患者中,肾脏系统活动等级患者比率冬季损害最高,其次为夏季和秋季患者,春季组的损害最轻。结论不同海拔地区和不同季节的SLE患者在人口学特征、临床特征分布、实验室特征分布有一定的差异,而不同活动性的患者部分器官的活动度与海拔、季节存在一定的关系。
[Abstract]:Objective to analyze the clinical manifestations of systemic lupus erythematosus (SLES) patients in different altitude areas and different seasons in Yunnan Province. Methods the clinical and laboratory data of 1 029 patients with SLE from January 2002 to December 2012 were analyzed retrospectively. Results 1. The altitude of the inpatients before admission ranged from 553 meters to 3,500 meters. The onset ages of the patients in the high altitude areas were smaller than those in the middle and low altitude areas. 2. With the increase of altitude, the hospitalized age of SLE patients was smaller. 2. The time from onset to first visit of SLE patients in high altitude area was shorter than that in middle altitude area. The positive rate of Anti-Sm antibody in high altitude area was higher than that in middle altitude area. The rate of anemia patients in high altitude area was higher than that in middle altitude area, and the rate of thrombocytopenia in low altitude area was lower than that in high altitude area. There was no significant difference between SLEDAI score and elevation in patients with elevated creatinine at high altitude. 5. In inactive patients with SLE, the immune system, The change of the ratio of patients with different grade of renal activity was related to the change of altitude, and with the increase of altitude, the change of the ratio of patients with different activity grade of mental nerve damage was related to the change of altitude, and the ratio of patients with different activity grade of mental nerve damage was related to the change of altitude in patients with SLE activity. With the increase of altitude, the ratio of patients with different levels of joint activity decreased with the elevation. 7. In the inpatients with SLE in the four seasons of spring, summer, autumn, winter, and four seasons, The onset age and hospitalization age of the patients were higher than those of the other three seasons in winter. Among the patients with SLE inactivity, the rate of immune system activity grade patients was the highest in spring, followed by autumn and summer patients. Among the patients with SLE activity, the rate of renal system activity grade was the highest in winter, followed by summer and autumn. Conclusion there are some differences in demographic, clinical and laboratory characteristics of patients with SLE in different altitude and different seasons, while the activity degree and altitude of some organs of patients with different activity are different. There is a certain relationship between seasons.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R593.241

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