补硒对自身免疫性甲状腺炎患者甲状腺抗体及T淋巴细胞亚群的影响

发布时间：2018-03-07 06:01

本文选题：自身免疫性甲状腺炎　切入点：硒　出处：《山东医药》2017年13期 　论文类型：期刊论文

【摘要】：目的探讨补硒对自身免疫性甲状腺炎患者甲状腺抗体及T淋巴细胞亚群的影响。方法自身免疫性甲状腺炎患者74例,按随机数字表法分为对照组(n=37)、补硒组(n=37)。两组均给予左甲状腺素片,每次50~125μg,1次/d,口服。补硒组给予硒酵母治疗,100μg/次,2次/d,口服。疗程均为6个月。分别在治疗前、治疗6个月对两组游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)水平及CD4~+/CD8~+、CD4~+T细胞百分比、CD8~+T细胞百分比进行检测。结果两组治疗前各指标比较,P均0.05;治疗前、治疗6个月,两组FT3、FT4、TSH差异无统计学意义(P均0.05)。与治疗前相比,治疗6个月,对照组TGAb、TPOAb水平均上升,而补硒组均下降,差异有统计学意义(P均0.05);治疗6个月,补硒组的TGAb、TPOAb水平均低于对照组(P均0.05)。与治疗前相比,治疗6个月补硒组CD4~+/CD8~+、CD4~+T细胞百分比均上升(P均0.05);治疗6个月,补硒组的CD4~+/CD8~+、CD4~+T细胞百分比均高于对照组(P均0.05)。结论对自身免疫性甲状腺炎患者进行补硒,可显著降低TGAb、TPOAb水平,增加CD4~+/CD8~+、CD4~+T细胞百分比。
[Abstract]:Objective to investigate the effect of selenium supplementation on thyroid antibodies and T lymphocyte subsets in patients with autoimmune thyroiditis. According to the random digital table method, the control group was divided into two groups: the control group (n = 37) and the selenium supplement group (n = 37). Both groups were given levothyroxine tablets, 50 ~ 125 渭 g / d, once a day. The selenium supplementation group was given 100 渭 g / d selenium yeast treatment twice a day for 6 months. The levels of free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), thyroglobulin antibody (TGAban), thyroid peroxidase antibody (TPOAbb) and the percentage of CD4 ~ / / CD8 ~ + CD4 ~ T cells were measured at 6 months after treatment. Results the indexes of the two groups before treatment were 0. 05; before treatment, there was no significant difference between the two groups. After 6 months of treatment, there was no significant difference in TSH between the two groups (P < 0.05). Compared with before treatment, the level of TGAb-TPOAb in the control group increased, while that in the selenium supplementation group decreased (P < 0.05), the level of TGAb-TPOAb in the control group increased after 6 months of treatment, the difference was statistically significant (P < 0.05), and the level of TPOAb in the control group decreased after 6 months of treatment. The levels of TGAb-TPOAb in the selenium supplementation group were lower than those in the control group (P < 0.05). The percentage of CD4 ~ / CD8 ~ + CD4T cells in the selenium supplementation group increased significantly after 6 months of treatment (P < 0.05), and the percentage of CD4 ~ T cells in the selenium supplementation group increased at 6 months after treatment (P < 0.05). The percentage of CD4 ~ / CD8 ~ + CD4T cells in selenium supplementation group was higher than that in control group (P < 0.05). Conclusion selenium supplementation can significantly decrease TGAb-TPOAb level and increase CD4 ~ / / CD8 ~ + CD4T cell percentage in patients with autoimmune thyroiditis.
【作者单位】：临沂市肿瘤医院;
【分类号】：R581.4

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