左卡尼汀对糖尿病腹膜透析患者外周血T细胞亚群及炎症因子的影响

发布时间：2018-03-08 14:43

本文选题：Th　切入点：Th　出处：《中国药房》2017年20期 　论文类型：期刊论文

【摘要】：目的:探讨左卡尼汀对糖尿病腹膜透析患者外周血T细胞及炎症因子的影响。方法:选取2013年9月-2015年10月宜昌市中心人民医院收治的100例糖尿病腹膜透析患者为研究对象,按随机数字表法分为常规治疗组和左卡尼汀组,各50例。常规治疗组患者给予腹膜透析治疗及常规治疗;左卡尼汀组患者在常规治疗组的基础上加用左卡尼汀1.0 g加入0.9%的氯化钠注射液20 m L中,每周3次,静脉注射,连续应用12周。两组患者均于治疗前后检测CD3~+、CD4~+、Th1、Th2及肿瘤坏死因子α(TNF-α)、干扰素γ(INF-γ)、白细胞介素10(IL-10),IL-4含量变化,并比较两组患者T-bet及GATA-3转录因子表达量。结果:治疗后,两组患者CD3~+、CD4~+、Th2细胞、GATA-3表达量及IL-10、IL-4水平均显著升高,Th1细胞、T-bet表达量及TNF-α、INF-γ水平显著降低,且左卡尼汀组显著优于常规治疗组,差异均有统计学意义(P0.05)。结论:左卡尼汀可通过改善T细胞亚群及Th1/Th2细胞亚群,从而改善患者的炎症状态,促进相关转录因子表达。
[Abstract]:Objective: to investigate the effect of levacarnitine on peripheral blood T cells and inflammatory factors in diabetic peritoneal dialysis patients. Methods: from September 2013 to October 2015, 100 diabetic peritoneal dialysis patients were selected from Yichang Central people's Hospital. The patients in the routine treatment group were divided into conventional treatment group (n = 50) and levocarnitine group (n = 50). The patients in the routine treatment group were treated with peritoneal dialysis and conventional therapy. The patients in the L-carnitine group were treated with L-carnitine 1.0 g plus 20 mL sodium chloride injection of 0.9%, 3 times a week, intravenously, on the basis of routine therapy. After 12 weeks of continuous use, the levels of CD3 ~ + CD4 ~ + Th1 Th2, TNF- 伪, IFN- 纬 -INF- 纬, IL-10, IL-10 and IL-4 were detected before and after treatment, and the expression of T-bet and GATA-3 transcription factors were compared between the two groups. In both groups, the expression of CD3 ~ + CD4 ~ + Th2 cells and the level of IL-10 ~ + IL-4 increased significantly, and the expression of T-bet and the level of TNF- 伪 -INF- 纬 in Th1 cells decreased significantly, and the levocarnitine group was significantly better than the routine treatment group. Conclusion: L-carnitine can improve the inflammatory state of patients and promote the expression of related transcription factors by improving T cell subsets and Th1/Th2 cell subsets.
【作者单位】：三峡大学第一临床医学院/宜昌市中心人民医院肾内科;三峡大学药学院;
【分类号】：R587.2;R692.5

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