无机元素与脆性骨折

发布时间：2018-03-08 18:20

本文选题：无机元素　切入点：脆性骨折　出处：《中国骨质疏松杂志》2017年11期 　论文类型：期刊论文

【摘要】：骨质疏松症是以骨密度下降和骨微结构破坏的一种系统性骨病,脆性骨折是骨质疏松症的主要并发症,而无机元素在体内的浓度水平与脆性骨折的发生率紧密相关,但分子作用机制尚未清楚。无机元素又分为3类,一类为常量元素,包括钙、磷和镁等元素;第2类为必需微量元素,包括氟、铜、铁、锌等元素;第3类为毒性重金属元素,包括汞、铅、铬等元素。无机元素在体内的浓度水平可能影响骨骼的生长发育和骨组织的代谢活动,如常量元素中的钙和磷元素是组成羟基磷灰石的主要成分,必需微量元素中的锌、铜和锰对骨形成和骨矿化有着不可或缺的作用,毒性重金属元素的铅和镉对骨组织有明显的毒性作用。本文就体内存在的多种无机元素与脆性骨折的关系作一综述,旨为预防和诊治骨质疏松症与脆性骨折提供一定的理论依据。
[Abstract]:Osteoporosis is a kind of systemic bone disease with bone mineral density decrease and bone microstructure destroyed. Brittle fracture is the main complication of osteoporosis. The concentration of inorganic elements in the body is closely related to the incidence of brittle fracture. However, the molecular mechanism of action has not yet been clarified. Inorganic elements are divided into three categories, one is constant elements, including calcium, phosphorus and magnesium, the second is essential trace elements, including fluorine, copper, iron and zinc, and the third is toxic heavy metal elements. Including mercury, lead, chromium, etc. Concentrations of inorganic elements in the body may affect the growth and development of bone and metabolism of bone tissue, such as calcium and phosphorus elements in constant elements are the main components of hydroxyapatite, Zinc, copper and manganese in essential trace elements play an indispensable role in bone formation and bone mineralization. Lead and cadmium of toxic heavy metal elements have obvious toxic effects on bone tissue. This paper reviews the relationship between various inorganic elements in vivo and brittle fracture. To provide a theoretical basis for the prevention and treatment of osteoporosis and brittle fracture.
【作者单位】：复旦大学附属华东医院骨科;
【基金】：上海市卫生和计划生育委员会课题(140612111756534) 上海市自然科学基金项目(15411951500) 上海市卫生计生系统重要薄弱学科建设计划(2015ZB0501)
【分类号】：R580;R683

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