唑来膦酸注射液联合金天格胶囊治疗绝经后骨质疏松症的临床观察

发布时间：2018-03-09 17:00

本文选题：唑来膦酸　切入点：金天格胶囊　出处：《中国药房》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨唑来膦酸注射液联合金天格胶囊治疗绝经后骨质疏松症(PMOP)的临床疗效及安全性。方法:选取海南省屯昌县人民医院2012年11月-2015年2月就诊的PMOP患者99例,按照随机数字表法分为对照组、单药组和联合组,各33例。对照组患者给予碳酸钙D3咀嚼片(Ⅱ)2片,po,qd+骨化三醇胶丸0.50μg,po,bid抗骨质疏松;单药组患者在对照组基础上给予唑来膦酸注射液5 mg,ivgtt,1次/年;联合组患者在单药组基础上给予金天格胶囊1.2 g,po,tid。3组患者均治疗12个月。比较3组患者治疗前后骨密度(BMD)、视觉模拟量表(VAS)评分和日常生活能力量表(ADL)评分,并记录不良反应发生情况。结果:治疗前,3组患者上述指标比较,差异均无统计学意义(P0.05)。治疗后,单药组和联合组患者BMD水平均较治疗前明显升高,且明显高于对照组,差异均有统计学意义(P0.05);单药组和联合组患者膝关节、腰背部VAS评分和ADL评分均较治疗前明显降低,且单药组明显低于对照组(ADL评分除外),联合组明显低于单药组,差异均有统计学意义(P0.05)。单药组和联合组患者的远期不良反应发生率(6.1%和3.0%)均明显低于对照组(21.2%),差异有统计学意义(P0.05)。结论:唑来膦酸注射液联合金天格胶囊可提高PMOP患者BMD,减轻患者膝关节及腰背部疼痛,且安全性较高。
[Abstract]:Objective: To investigate the effect of Zoledronic Acid Injection combined with Jintiange capsules in the treatment of postmenopausal osteoporosis (PMOP) clinical efficacy and safety. Methods: 99 patients with PMOP from November 2012 Hainan province people's Hospital of Tunchang County -2015 year in February were patients, randomly divided into control group, single drug group and combined group, 33 cases. The control group were treated with D3 of Calcium Carbonate Chewable Tablets (II) 2, Calcitriol Soft Capsules Po, qd+ 0.50 g, Po, bid, anti osteoporosis; single drug group patients in the control group on the basis of Zoledronic Acid Injection IVGTT, 5 mg, 1 times / year; the joint group were treated with Jintiange capsules 1.2 g. Po in the monotherapy group on the basis of tid.3, the patients were treated for 12 months. The 3 groups were compared before and after treatment of bone mineral density (BMD), visual analogue scale (VAS) score and daily life ability scale (ADL) score, and record the occurrence of adverse reactions. Results: before treatment, the patients in the 3 groups refers to Standard comparison, there were no significant differences (P0.05). After treatment, the BMD levels of patients with single drug group and combined group were significantly higher than those before treatment, and was significantly higher than the control group, the differences were statistically significant (P0.05); single drug group and combined group of patients with knee joint, lumbar VAS score and ADL score were before treatment was significantly reduced, and the single drug group was significantly lower than the control group (ADL scores except), combination group was significantly lower than that of the single drug group, the differences were statistically significant (P0.05). The incidence of long-term adverse effects of single drug group and combined group (6.1% and 3%) were significantly lower than the control group (21.2%), there was statistical significant differences (P0.05). Conclusion: Zoledronic Acid Injection combined with Jintiange capsules can improve PMOP in patients with BMD, reduce knee and back pain, and high safety.

【作者单位】：海南省屯昌县人民医院妇产科;海南省农垦总医院妇产科;
【分类号】：R580

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