谷赖胰岛素与门冬胰岛素治疗胰岛β细胞功能衰竭2型糖尿病的疗效与安全性比较

发布时间：2018-03-09 20:48

本文选题：谷赖胰岛素　切入点：门冬胰岛素　出处：《中国现代医学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的探讨谷赖胰岛素与门冬胰岛素联合甘精胰岛素在治疗胰岛β细胞功能衰竭2型糖尿病的疗效与安全性差异。方法选取2015年12月-2016年6月于吉林大学第二医院内分泌科住院及门诊治疗的胰岛β细胞功能衰竭的2型糖尿病患者68例。所有入选患者进行糖尿病宣传教育、饮食及运动控制,监测每日空腹、餐前、三餐后2 h及睡前血糖。入选患者随机分为两组,实验组给予谷赖胰岛素联合甘精胰岛素皮下注射降糖治疗,对照组给予门冬胰岛素联合甘精胰岛素皮下注射降糖治疗,比较两组在治疗前后空腹、餐前、三餐后2 h睡前血糖变化、日需胰岛素剂量、糖化血红蛋白(Hb A1c)变化及低血糖发生次数。结果 (1)经过3个月的治疗随访观察,两组在空腹、餐前、三餐后2 h、睡前血糖及糖化血红蛋白上均较治疗前有下降(P0.05);(2)两组在控制血糖达标所需日胰岛素剂量比较差异无统计学(P0.05);(3)对照组在餐前及夜间血糖控制上优于实验组(P0.05);(4)实验组在控制餐后2 h血糖上优于对照组(P0.05);(5)两组在糖化血红蛋白控制上差异无统计学(P0.05);(6)实验组的低血糖次数少于对照组,差异有统计学意义(P0.05)。结论谷赖胰岛素联合甘精胰岛素较门冬胰岛素联合甘精胰岛素能更好控制胰岛β细胞功能衰竭2型糖尿病的血糖,耐受好、低血糖发生次数少及降低血糖波动,减少或延缓糖尿病的各种急慢性并发症发生。
[Abstract]:Objective to investigate the efficacy and safety of insulin aspartate combined with insulin gluconate in the treatment of type 2 diabetes mellitus with islet 尾 cell failure. Methods from December 2015 to June 2016, the patients were selected at the second Hospital of Jilin University. Sixty-eight patients with type 2 diabetes with islet 尾 cell failure treated in and out of the department of Endocrinology. All patients were enrolled in diabetes publicity and education. Diet and exercise control, daily fasting, pre-meal, two hours after three meals and before bedtime blood glucose were monitored. The patients were randomly divided into two groups. The experimental group was treated with subcutaneous injection of glutaline insulin and insulin glargine. The control group was treated with insulin asparagus combined with hypoglycemic injection of insulin glargine. The changes of blood glucose before and after fasting, before and after three meals were compared between the two groups, and the daily insulin dose was needed. The changes of HbA1c and the frequency of hypoglycemia. Results: after 3 months of treatment, the two groups were observed before and before meal. Two hours after three meals, blood glucose and glycosylated hemoglobin before bedtime were lower than those before treatment (P 0.05). There was no significant difference in the daily insulin dose needed to control blood glucose in the two groups. There was no significant difference between the two groups (P 0.05)) the control group was superior to the experimental group in the control of blood glucose before meal and at night. The control of blood glucose in the experimental group was better than that in the control group in 2 h postprandial hyperglycemia) there was no significant difference in the control of glycosylated hemoglobin between the two groups (P 0.05) the number of hypoglycemia in the experimental group was lower than that in the control group. Conclusion compared with aspartic insulin combined with insulin glargine, the blood glucose of type 2 diabetic patients with islet 尾 cell failure can be controlled better and tolerated better than that of aspartic insulin combined with insulin glargine. Hypoglycemia occurs less often and reduces the fluctuation of blood sugar, reducing or delaying the occurrence of various acute and chronic complications of diabetes.
【作者单位】：吉林大学第二医院内分泌科;
【分类号】：R587.1

【相似文献】