应用寄生虫模型治疗多发性硬化症的研究进展

发布时间：2018-03-10 05:11

本文选题：寄生虫　切入点：治疗　出处：《中国病原生物学杂志》2017年01期 　论文类型：期刊论文

【摘要】：多发性硬化(multiple sclerosis,MS)是一种严重危害人类健康的中枢神经系统的慢性脱髓鞘性炎性疾病。近年来MS的发病率越来越高,"卫生假说"认为其可能是由于患者儿童时期较少接触病原体所致。大量流行病学数据与动物研究结果表明,寄生虫作为一类较成功的病原体,可主动调节宿主免疫应答,营造抗炎的免疫环境,从而缓解MS病情。其可通过多种机制下调炎症反应,包括抑制Th1/Th17反应,促进Th2反应,诱导调节性T细胞(regulatory T cells,Treg)和调节性B细胞(regulatory B cells,Breg),调节树突状细胞功能等。其中,以诱导Treg及抗炎因子IL-10、TGF-β的产生最为重要。本文就寄生虫感染治疗MS的流行病学证据、免疫调节机制及应用前景进行综述。
[Abstract]:Multiple sclerosis (MS) is a chronic demyelinating inflammatory disease of the central nervous system which is seriously harmful to human health. The incidence of MS has been increasing in recent years. Due to low exposure to pathogens. A great deal of epidemiological data and animal studies show that, As a successful pathogen, parasites can actively regulate the host immune response, create an anti-inflammatory immune environment, and thus alleviate the condition of MS. It can down-regulate inflammatory response, including inhibiting Th1/Th17 response, and promoting Th2 response through a variety of mechanisms. Inducible regulatory T cells Tregand regulatory B cells Bregn, regulating dendritic cell function, etc. Among them, it is most important to induce the production of Treg and anti-inflammatory factor IL-10 TGF- 尾. The epidemiological evidence for the treatment of parasitic infection with MS was reviewed. The mechanism of immunomodulation and its application prospect were reviewed.
【作者单位】：徐州医科大学病原生物学与免疫学教研室感染与免疫实验室;徐州医科大学临床医学系;
【基金】：国家自然科学基金项目(No.81371842) 江苏省教育厅高校自然科学研究基金面上项目(No.15KJB310025) 江苏省自然科学基金面上项目(No.BK20151168) 江苏省博士后科研资助计划(No.1501061A) 大学生创新创业训练计划项目基金(No.201510313017Z,201510313017)
【分类号】：R744.51

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