银丹心脑通软胶囊联合瑞舒伐他汀钙和硫酸氢氯吡格雷对伴有2型糖尿病急性脑梗死患者血脂、颈动脉粥样硬化斑块及神经功能恢复的影

发布时间：2018-03-10 10:15

本文选题：银丹心脑通软胶囊　切入点：瑞舒伐他汀钙　出处：《中草药》2016年15期 　论文类型：期刊论文

【摘要】：目的探讨银丹心脑通软胶囊联合瑞舒伐他汀钙和硫酸氢氯吡格雷对伴有2型糖尿病急性脑梗死患者血脂、颈动脉粥样硬化(CAS)斑块及神经功能恢复的影响。方法选择2013年5月—2015年1月于天津医院收治的伴有2型糖尿病脑梗死患者150例,经颈动脉彩色超声证实有颈动脉斑块。所选病例随机分为两组,每组75例。两组在基础病治疗基础上,对照组给予瑞舒伐他汀钙片10 mg/d(每日1次)及硫酸氢氯吡格雷75 mg/d(每日1次),口服;治疗组在对照组基础上给予银丹心脑通软胶囊每次3粒(0.4 g/粒),每日3次。两组均进行饮食控制,根据病情给予控制血压、血糖及其他基础疾病药物治疗。检测两组治疗前及治疗12个月后血脂水平;统计两组颈动脉斑块总数、测量斑块内膜-中层厚度(IMT)及判定斑块性质;于治疗前后对两组患者进行神经功能评分及疗效判定;统计两组终点事件发生情况。结果疗程结束后,两组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)降低,高密度脂蛋白胆固醇(HDL-C)升高,但治疗组LDL-C较对照组明显降低(P0.05);两组颈部IMT较治疗前明显降低,但治疗组斑块面积较对照组明显缩小(P0.05);治疗组的神经功能评分较对照组明显减低(P0.05);治疗组疗效显著优于对照组(P0.01),治疗组药物不良反应发生率低于对照组(P0.05)。结论银丹心脑通软胶囊联合瑞舒伐他汀钙和硫酸氢氯吡格雷治疗伴有2型糖尿病急性脑梗死患者的高脂血症及CAS斑块疗效显著。
[Abstract]:Objective to investigate the effects of Yindan Xinnaotong soft capsule combined with recuvastatin calcium and hydroclopidogrel sulfate on blood lipids in patients with acute cerebral infarction with type 2 diabetes mellitus. Effects of carotid Atherosclerosis on plaque and nerve function recovery methods 150 patients with type 2 diabetic cerebral infarction were treated in Tianjin Hospital from May 2013 to January 2015. Carotid plaques were confirmed by carotid color ultrasound. The selected cases were randomly divided into two groups, 75 cases in each group. The control group was given 10 mg / d of rosuvastatin calcium tablets (once a day) and 75 mg / d of clopidogrel sulfate (once a day). On the basis of the control group, the treatment group was given Yindan Xinnaotong soft capsule with 3 capsules of 0.4 g / g per capsule, 3 times a day. The two groups were given diet control and blood pressure control according to the condition of the disease. Blood glucose and other basic diseases were treated with drugs. The blood lipid levels were measured before and after 12 months of treatment in both groups, the total number of carotid plaques in the two groups was counted, the intima-media thickness of plaques was measured and the plaque nature was determined. Before and after treatment, the patients in both groups were evaluated for neurological function and curative effect, and the occurrence of terminal events in the two groups was counted. Results after the course of treatment, the levels of serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TGG) in the two groups were decreased. High density lipoprotein cholesterol (HDL-C) was increased, but LDL-C in the treatment group was significantly lower than that in the control group (P 0.05), and IMT in the neck of the two groups was significantly lower than that before treatment. However, the plaque area in the treatment group was significantly smaller than that in the control group, the nerve function score in the treatment group was significantly lower than that in the control group, the curative effect in the treatment group was significantly better than that in the control group, and the incidence of adverse drug reactions in the treatment group was lower than that in the control group. Danxinnaotong soft capsule combined with recuvastatin calcium and hydroclopidogrel sulfate was effective in the treatment of hyperlipidemia and CAS plaque in patients with acute cerebral infarction with type 2 diabetes.
【作者单位】：天津医科大学总医院;天津市天津医院神经科;天津医科大学总医院神经内科;
【分类号】：R587.1;R743.3

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