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非布司他治疗痛风性关节炎的疗效及其安全性评价

发布时间:2018-03-10 15:19

  本文选题:非布司他 切入点:痛风性关节炎 出处:《吉林大学学报(医学版)》2017年01期  论文类型:期刊论文


【摘要】:目的:观察非布司他治疗痛风性关节炎的疗效及治疗前后患者受累关节彩色超声图像的变化。方法:选择66例男性痛风性关节炎患者,根据药物使用情况分为非布司他组(非布司他40 mg·d-1,n=37)和别嘌醇组(别嘌醇100mg·d-1,n=29),观察2组患者治疗前后血尿酸(UA)、血脂水平和滑膜周围血流信号及受累关节的彩色多普勒超声图像的变化。结果:2组患者治疗后血UA水平下降,与治疗前比较差异均有统计学意义(P0.05);在16、20和24周,非布司他组患者达到目标血UA值的百分率均较别嘌醇组高,2组间比较差异有统计学意义(P0.05)。与治疗前比较,治疗后非布司他组患者高密度脂蛋白(HDL)水平明显升高(P=0.001),而总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白(LDL)水平无明显变化(P0.05);别嘌醇组患者治疗前后TC、HDL、LDL和TG水平均无明显变化(P0.05)。2组患者治疗后大部分痛风结晶消失(非布司他组占71.4%,别嘌醇组占58.9%),非布司他组较别嘌醇组痛风结晶溶解效果更佳。2组患者痛风急性发作期的关节腔积液、关节周围软组织肿胀和滑膜周围血流信号均有改善,但2组之间比较未见明显差别。2组患者痛风慢性发作期表现比较无明显差异。结论:非布司他可更有效地降低痛风性关节炎患者血UA水平,改善痛风急性发作期表现,痛风结晶溶解效果更佳。
[Abstract]:Objective: to observe the therapeutic effect of Festa on gouty arthritis and the changes of color ultrasound images of involved joints before and after treatment. Methods: 66 male patients with gouty arthritis were selected. According to the drug use, the patients were divided into two groups: non-buflast group (40 mg 路d ~ (-1)) and allopurinol group (100 mg 路d ~ (-1)) allopurinol. Before and after treatment, the levels of serum uric acid and UAA, blood lipid level, peripheral blood flow signal and color Doppler flow of the involved joints were observed in both groups. Results the serum UA level decreased after treatment in two groups of patients. There were significant differences between before and after treatment (P 0.05), and at the 20th and 24th weeks after treatment, the percentage of patients in the non-busulta group who reached the target blood UA value was significantly higher than that in the allopurinol group (P 0.05), and was significantly higher than that in the allopurinol group (P 0.05), and was significantly higher than that in the control group (P < 0.05). After treatment, high density lipoprotein (HDL) levels were significantly increased in patients with Festalta group, but the levels of TC, TG, TGG and LDL were not significantly changed (P 0.05), while in allopurinol group there were no significant changes in LDL and TG levels of TCU before and after treatment, and there was no significant change in the levels of TCU HDLLDL and TG in allopurinol group before and after treatment. Most of the gout crystals disappeared after treatment (71.4% in the non-Budesta group, 58.9% in the allopurinol group, better dissolution of gout crystals in the non-Budesta group than in the allopurinol group. The swelling of the soft tissue around the joint and the blood flow signal around the synovium were improved. However, there was no significant difference between the two groups. Conclusion: the blood UA level of patients with gouty arthritis can be reduced more effectively, and the symptoms of gout acute attack can be improved. The effect of gout crystal dissolution is better.
【作者单位】: 吉林大学第一医院风湿免疫科;
【基金】:吉林省科技厅科技发展计划项目资助课题(20150101152JC)
【分类号】:R589.7

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