糖尿病相关脑微血管病变研究进展

发布时间：2018-03-13 02:30

本文选题：糖尿病　切入点：脑微血管病变　出处：《中国中药杂志》2017年12期 　论文类型：期刊论文

【摘要】：糖尿病是一种慢性代谢障碍性疾病,随着发病率的逐年增高,已成为人类健康的主要威胁之一。脑微血管病变是糖尿病的特征性病理改变,是糖尿病脑部慢性并发症的病理基础,主要见于阿尔茨海默症和腔隙性脑梗死患者,是导致糖尿病患者致死致残的主要原因之一。其致病机制复杂,涉及多元醇代谢异常、糖化反应亢进、氧化应激、β淀粉样蛋白跨血脑屏障的异常转运、蛋白激酶C激活等多个方面,以发病机制为靶点的治疗可能会为预防和延缓糖尿病脑微血管病变的发生发展带来新的希望。目前,对糖尿病脑微血管病变的机制、诊断和治疗方法的研究较为广泛,已成为医学研究的一大热点。该文拟对糖尿病诱发的脑微血管病变的发病机制,临床诊断与治疗策略方面的研究进行综述,以期为糖尿病脑微血管病变的预防和治疗提供新的思路。
[Abstract]:Diabetes mellitus (DM) is a chronic metabolic disorder. With the increasing incidence of diabetes, it has become one of the main threats to human health. It is the pathological basis of chronic complications of diabetic brain, mainly found in patients with Alzheimer's disease and lacunar cerebral infarction, and is one of the main causes of death and disability in diabetic patients. Hyperglycosylation, oxidative stress, abnormal transport of 尾 -amyloid across the blood-brain barrier, activation of protein kinase C, etc. Treatment targeting the pathogenesis may bring new hope to prevent and delay the occurrence and development of diabetic cerebral microangiopathy. At present, the mechanism, diagnosis and treatment of diabetic cerebral microangiopathy are widely studied. This article reviews the pathogenesis, clinical diagnosis and treatment strategies of diabetic cerebral microangiopathy. In order to provide new ideas for the prevention and treatment of diabetic cerebral microangiopathy.
【作者单位】：北京大学第一医院中西医结合研究室;北京大学药学院天然药物与仿生药物国家重点实验室;
【基金】：国家自然科学基金重点项目(81530099)
【分类号】：R587.2;R743

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