枸杞多糖联合二甲双胍治疗2型糖尿病患者的疗效及对免疫功能的影响

发布时间：2018-03-14 09:51

本文选题：枸杞多糖　切入点：二甲双胍　出处：《中国老年学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的探讨枸杞多糖联合二甲双胍治疗2型糖尿病(T2DM)患者对机体免疫功能的影响。方法 T2DM患者94例按照随机数字表法分为对照组和观察组,每组47例。对照组给予口服二甲双胍治疗,观察组加用枸杞多糖进行治疗,疗程均为3个月。统计两组整体临床疗效,分别于治疗前后检测患者的空腹血糖(FPG)、口服葡萄糖2 h后血糖(2 h PBG)、糖化血红蛋白(Hb A1c)和空腹血清胰岛素(FINS)水平,另外采用流式细胞仪检测外周血中T淋巴细胞亚群及常规检测血清中免疫球蛋白(Ig A、Ig G、Ig M)水平。观察患者不良反应发生情况。结果观察组总有效率明显高于对照组(P0.05);治疗后,除FINS水平显著高于治疗前外,所有患者的其他血糖指标水平均明显低于治疗前,同时观察组改善效果明显优于对照组(P0.05);除CD8~+水平无明显变化外,患者治疗后CD3~+、CD4~+及CD4~+/CD8~+水平明显高于治疗前(P0.05);与治疗前相比Ig A和Ig G水平明显下降,而Ig M水平显著升高(P0.05),观察组T淋巴细胞亚群水平改善情况显著优于对照组(P0.05);两种治疗方案诱发的不良反应差异无统计学意义(P0.05)。结论枸杞多糖联合二甲双胍治疗T2DM患者的临床疗效明显,在改善患者血糖水平的同时可解除对患者免疫功能的抑制作用,安全可行,可作为临床治疗T2DM的新思路之一。
[Abstract]:Objective to investigate the effect of Lycium barbarum polysaccharides combined with metformin on immune function of patients with type 2 diabetes mellitus (T2DM). Methods 94 patients with T2DM were divided into control group and observation group according to random digital table. There were 47 cases in each group. The control group was treated with metformin orally and the observation group was treated with Lycium barbarum polysaccharide for 3 months. Before and after treatment, fasting blood glucose (FPG) and fasting serum insulin (FINS) were measured, and the levels of PBGN, HbA1c, HbA1c and fasting serum insulin (FINS) were measured 2 hours after oral glucose. In addition, flow cytometry was used to detect T lymphocyte subsets in peripheral blood and serum immunoglobulin G G G M was detected by routine method. Adverse reactions were observed. Results the total effective rate of the observation group was significantly higher than that of the control group (P 0.05), and after treatment, the total effective rate of the observation group was significantly higher than that of the control group (P 0.05). The level of blood glucose in all patients was significantly lower than that before treatment, and the improvement effect of observation group was better than that of control group (P 0.05), except for CD8 ~, there was no significant change in the level of CD8 ~, except that the level of FINS was significantly higher than that of the control group (P < 0.05). After treatment, the levels of CD3 ~ + CD4 ~ and CD4 ~ / / CD8 ~ ~ were significantly higher than those of P0.05A and IgG, and the levels of IgA and IgG were significantly lower than those before treatment. The level of IgM was significantly higher than that of the control group (P 0.05), and the improvement of T lymphocyte subsets in the observation group was significantly better than that in the control group (P 0.05), and there was no significant difference in the adverse reactions induced by the two treatments. Conclusion the treatment of Lycium barbarum polysaccharides combined with metformin is of no statistical significance. The clinical effect of T2DM patients was obvious. It is safe and feasible to improve the blood glucose level and relieve the inhibition of immune function in patients with T2DM. It can be used as one of the new ideas for clinical treatment of T2DM.
【作者单位】：枣庄矿业集团中心医院内分泌科;
【分类号】：R587.1

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