跑台运动对阿霉素联合醋酸戈舍瑞林诱导骨质疏松大鼠骨密度和骨代谢的影响

发布时间：2018-03-15 01:11

  本文选题：跑台运动　切入点：阿霉素　出处：《中国骨质疏松杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的研究阿霉素(doxorubicin,DOX)和醋酸戈舍瑞林(goserelin acetate,GA)联合作用对大鼠骨密度和骨代谢的影响,以及跑台运动对DOX联合GA诱导的大鼠骨质疏松的防治效果。方法 8周龄雌性SD大鼠64只,被随机分为8组,每组8只:安静对照组(SED)、DOX干预组(SED+DOX)、GA干预组(SED+GA)、DOX和GA联合干预组(SED+DOX+GA)、跑台运动对照组(EX)、跑台运动结合DOX干预组(EX+DOX)、跑台运动结合GA干预组(EX+GA)、跑台运动结合DOX和GA联合干预组(EX+DOX+GA)。药物和跑台运动干预周期均为8周,8周后测试所有大鼠左侧股骨骨密度和血清骨代谢指标。结果与其相对应的非药物干预各组相比较,药物干预各组大鼠骨密度显著降低、骨形成指标ALP和BGP显著降低而骨吸收指标Ca2+和TRACP5b显著升高;与DOX单独干预组及GA单独干预组相比较,DOX和GA联合干预组大鼠骨密度显著降低、骨形成指标ALP和BGP显著降低而骨吸收指标Ca2+和TRACP5b显著升高;与其相对应的安静组相比较,跑台运动各组大鼠骨密度显著升高、骨形成指标ALP和BGP显著升高而骨吸收指标Ca2+和TRACP5b显著降低。结论 DOX和GA单独或联合作用均可导致大鼠骨质疏松症的发生,且DOX和GA联合作用诱导大鼠骨质疏松的程度显著大于DOX或GA单独作用的结果;跑台运动可以有效降低DOX和GA单独或联合作用诱导的大鼠骨质疏松。
[Abstract]:Objective to study the adriamycin (doxorubicin, DOX) and Gore Sherry Lin (goserelin acetate, GA acetate) combined effects on bone density and bone metabolism in rats, and the control effect of treadmill exercise on DOX combined with GA induced osteoporosis rats. Methods 8 week old female SD 64 rats were randomly divided into 8 group, 8 rats in each group: control group (SED), DOX group (SED+DOX), GA group (SED+GA), DOX and GA treatment group (SED+DOX+GA), treadmill exercise control group (EX), treadmill exercise combined with DOX intervention group (EX+DOX), treadmill exercise intervention combined with GA group (EX+GA), treadmill exercise combined with DOX and GA treatment group (EX+DOX+GA). Drugs and treadmill exercise intervention period was 8 weeks, 8 weeks after the test of all the rats left femur bone mineral density and bone metabolism indexes. Non drug intervention groups compared with the corresponding results, drug intervention groups the bone density was significantly decreased, bone formation As indicators of ALP and BGP significantly decreased and the bone absorption index of Ca2+ and TRACP5b were significantly increased; with DOX alone GA alone intervention group and intervention group compared, DOX and GA combined intervention group rats significantly decreased bone density, bone formation index ALP and BGP significantly decreased and the bone absorption index of Ca2+ and TRACP5b significantly increased; and the relative should the quiet group compared with treadmill exercise rats significantly increased the bone density, bone formation index ALP and BGP were significantly increased and the bone resorption index of Ca2+ and TRACP5b decreased significantly. Conclusion DOX and GA alone or in combination can lead to osteoporosis rats occurred, and the combined effects of DOX and GA induced rats osteoporosis was significantly higher than DOX or GA alone. Results; treadmill exercise can effectively reduce the induction of DOX and GA alone or in combination with the function of rats with osteoporosis.

【作者单位】： 山东体育学院;齐鲁师范学院;
【基金】：国家体育总局全民健身研究领域课题(2015B059);国家体育总局体育哲学社会科学研究项目(2292SS16029)
【分类号】：R580
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本文编号：1613754